CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
病例报告：接受 CAR-T 细胞治疗的 B 细胞急性淋巴细胞白血病患者出现伪装为真菌性眼内炎的双侧视神经乳头肿物及视网膜病变
英文原题：Case Report: Bilateral optic nerve head masses and retinopathy in a patient with B-cell acute lymphoblastic leukemia receiving CAR T-cell therapy masquerading as fungal endophthalmitis.
查看英文原题
Case Report: Bilateral optic nerve head masses and retinopathy in a patient with B-cell acute lymphoblastic leukemia receiving CAR T-cell therapy masquerading as fungal endophthalmitis.
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中文摘要
嵌合抗原受体（CAR）T细胞可穿越组织屏障，因此具有清除其他全身治疗无法到达的免疫豁免部位病灶的显著潜力。这种独特能力虽带来重要临床获益，但也伴随特殊的潜在毒性。肿瘤炎症相关神经毒性（TIAN）表现为中枢神经系统（CNS）肿瘤部位的局部炎症性毒性，推测始于CAR-T 细胞穿越血脑屏障（BBB）。具体而言，影响视网膜和视神经的CAR-T 治疗眼部毒性可能是TIAN的一种表现，但相关报道较少。我们介绍一例特殊病例：一名接受CAR-T 治疗的B细胞急性淋巴细胞白血病患者出现双侧视神经乳头肿块和视网膜病变，表现类似真菌性眼内炎。早期识别并采取多学科诊疗后，此类眼部TIAN可得到有效管理。
展开英文摘要原文
Chimeric antigen receptor (CAR) T cells can traffic across tissue planes and thus have considerable potential to clear disease in sanctuary sites inaccessible to alternate systemic treatments. While of great clinical benefit, this unique capability is associated with distinctive potential toxicity.
Tumor inflammation-associated neurotoxicity (TIAN) is characterized by local inflammatory toxicity at tumor sites within the CNS, presumably initiated by CAR T cells penetrating the blood-brain barrier (BBB). Specifically, ocular toxicity of CAR T-cell treatment affecting the retina and optic nerve may represent a variant of TIAN and has been infrequently described.
We highlight a unique case of bilateral optic nerve head masses and retinopathy masquerading as fungal endophthalmitis in a patient with B-cell ALL treated with CAR T-cell therapy. With early recognition and a multidisciplinary approach, such cases of ocular TIAN can be effectively managed.
论文信息
- 作者
- Heng JS、Ramos-Davila E、Maiz AM、Henderson A、Eberhart CG、Liberman P、Métais JY、Gottschalk S
- 单位
- Retina Division, Wilmer Eye Institute, The Johns Hopkins Hospital, Baltimore, MD, United States.United States
- 文献类型
- 病例报告
- 期刊
- Frontiers in immunology2026
- 原文标识
- PubMed 42367755 · DOI 10.3389/fimmu.2026.1854882
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