CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
中枢神经系统多发性骨髓瘤：2026 年更新
英文原题：Central nervous system multiple myeloma: An update for 2026.
查看英文原题
Central nervous system multiple myeloma: An update for 2026.
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中文摘要
中枢神经系统多发性骨髓瘤（CNS-MM）是一种罕见但高度侵袭性的浆细胞疾病，预后较差。CNS-MM是具有独特诊断挑战和治疗耐药性的临床实体。传统疗法既往疗效不佳，中位生存期以月计。现代诊断依赖综合评估神经系统症状、先进的脑脊液流式细胞术和高分辨率影像，但目前尚无统一诊断标准。在当前治疗时代，结合放疗、可穿透血脑屏障药物及免疫治疗的多模式策略拓展了治疗选择。双特异性抗体和CAR-T 疗法显示出前所未有的中枢神经系统特异性缓解率，但现有数据仍有限。本综述总结CNS-MM的流行病学、危险因素、诊断和治疗现状，重点介绍新兴免疫治疗方法及仍待解决的认知空白。
展开英文摘要原文
Central nervous system multiple myeloma (CNS-MM) is a rare yet highly aggressive plasma cell dyscrasia with a poor prognosis. CNS-MM represents a distinct clinical entity characterized by unique diagnostic challenges and therapeutic resistances. Conventional therapies have historically yielded dismal outcomes, with median survival measured in months. Modern diagnosis relies on integrating neurological symptoms, advanced CSF flow cytometry, and high-resolution imaging; however, unified diagnostic criteria remain lacking.
In the modern era, multimodal strategies incorporating radiotherapy, BBB-penetrating agents, and immunotherapy have expanded treatment options. Bispecific antibodies and CAR-T therapy demonstrate unprecedented CNS-specific response rates, although data remain limited. This review synthesizes current evidence on CNS-MM epidemiology, risk factors, diagnostics, and therapeutics, highlighting emerging immunotherapeutic approaches and persistent knowledge gaps.
论文信息
- 作者
- Wang B、Li W、Liu M、Zhou H、Jin X、Wang W、Ge S、Gao W
- 第一作者单位
- Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.China
- 通讯作者单位
- Department of Hematology, Myeloma Research Center of Beijing, Beijing Branch Center of the National Clinical Research Center for Hematologic Diseases, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. gaowenpingping@mail.ccmu.edu.cn.China
- 文献类型
- 综述
- 期刊
- Annals of hematology2026 Jun 12
- 原文标识
- PubMed 42277324 · DOI 10.1007/s00277-026-07114-w
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