纵向血浆代谢组学指导食管鳞状细胞癌化疗免疫治疗的动态风险评估与饮食调节
Longitudinal Plasma Metabolomics Guides Dynamic Risk Assessment and Dietary Modulation for Esophageal Squamous Cell Cancer Chemoimmunotherapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
信迪利单抗相关噬血细胞性淋巴组织细胞增生症：1 例病例报告
英文原题：Sintilimab-associated hemophagocytic lymphohistiocytosis: a case report.
查看英文原题
Sintilimab-associated hemophagocytic lymphohistiocytosis: a case report.
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中文摘要
噬血细胞性淋巴组织细胞增多症（HLH）是一种罕见的血液系统综合征，特征为细胞因子大量且失控释放，可导致多器官衰竭，死亡率较高。近期研究发现，免疫检查点抑制剂（ICI）可诱发HLH。本病例报告一名75岁转移性食管鳞状细胞癌（ESCC）男性患者发生信迪利单抗相关HLH，表现为难治性发热和呼吸道症状，最初被误诊为感染。铁蛋白升高、sCD25升高和NK细胞活性降低支持确诊，但由于症状缺乏特异性，诊断延迟。开始地塞米松治疗后，患者症状消退、实验室指标恢复正常，并达到完全缓解。本病例提示HLH是免疫检查点抑制剂罕见但危及生命的免疫相关不良事件，强调对不明原因发热患者尽早开展多学科讨论（MDT）的重要性，并表明早期诊断和治疗至关重要。
展开英文摘要原文
Hemophagocytic lymphohistiocytosis (HLH) is a rare hematologic syndrome characterized by massive, uncontrolled cytokine release, which can lead to multiple organ failure and is associated with a high mortality rate. Recent studies have found that checkpoint inhibitors (ICIs) can induce HLH. This case report describes a 75-year-old man with metastatic esophageal squamous cell carcinoma (ESCC) who developed sintilimab-associated HLH, presenting as refractory fever and respiratory symptoms initially misdiagnosed as infection.
The diagnosis, confirmed via elevated ferritin, sCD25, and reduced NK-cell activity, was delayed due to nonspecific symptoms. Following the initiation of dexamethasone, the patient's symptoms resolved and laboratory parameters normalized, leading to complete remission. The case highlights HLH as a rare but life-threatening immune-related adverse event of checkpoint inhibitors, underscores the importance of early multidisciplinary discussion (MDT) in patients with unexplained fever, and demonstrates the early diagnosis and treatment are critical.
论文信息
- 作者
- Zhi J、Wang X、Feng B、Zhao W、Wang B、Jia Y
- 单位
- Department of Oncology, Hebei General Hospital, Shijiazhuang, China.China
- 文献类型
- 病例报告
- 期刊
- Frontiers in immunology2026
- 原文标识
- PubMed 42245646 · DOI 10.3389/fimmu.2026.1821839
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