CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
急性髓系白血病靶向免疫治疗干预与 CAR-T 治疗的演变格局
英文原题：Evolving landscape of targeted immunotherapeutic interventions and CAR-T therapy for acute myeloid leukemia.
查看英文原题
Evolving landscape of targeted immunotherapeutic interventions and CAR-T therapy for acute myeloid leukemia.
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中文摘要
急性髓系白血病是一种侵袭性且高度异质的疾病，其特征为白血病原始细胞异常增殖及骨髓生态位重塑。传统疗法难以控制不断演变且耐药的AML亚型。CAR-T 细胞、免疫检查点抑制剂、抗体药物偶联物和抗体类治疗等新一代免疫疗法，可靶向白血病原始细胞。本综述旨在全面概述用于应对AML的免疫治疗策略演进、挑战和突破。
展开英文摘要原文
Acute myeloid leukemia is an aggressive and heterogeneous disease characterized by abnormal proliferation of leukemic blast cells and niche remodeling. Traditional therapies fail to manage evolving and resistant AML subtypes.
Next-generation immunotherapeutic interventions, such as CAR-T cells, immune checkpoint inhibitors, antibody-drug conjugates, and antibody-based therapeutics, target leukemic blast cells. This review aims to provide a comprehensive overview of the evolving landscapes of immunotherapeutic strategies, challenges, and breakthroughs in tackling AML.
论文信息
- 作者
- Yadav TC、Mohiyuddin S、Hildebrandt GC、Palaniyandi S
- 第一作者单位
- Division of Hematology and Medical Oncology, Department of Medicine, Ellis Fischel Cancer Center, University of Missouri, Columbia, MO, USA.United States
- 通讯作者单位
- Division of Hematology and Medical Oncology, Department of Medicine, Ellis Fischel Cancer Center, University of Missouri, Columbia, MO, USA. s.palaniyandi@health.missouri.edu.United States
- 文献类型
- 综述
- 期刊
- NPJ precision oncology2026 Jun 3
- 原文标识
- PubMed 42237008 · DOI 10.1038/s41698-026-01541-8
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