儿童血液系统恶性肿瘤治疗相关心血管事件机制研究的最新进展

This narrative review synthesizes the most recent advances in elucidating the mechanisms underlying cardiovascular events associated with the treatment of pediatric hematologic malignancies. First, this review delineates the principal therapeutic modalities currently employed, including chemotherapy, radiotherapy, cellular immunotherapy, and small-molecule targeted therapy.

Subsequently, this review offers a systematic and nuanced appraisal of the mechanisms through which these treatments precipitate cardiovascular injury, encompassing direct cardiotoxic effects, inflammatory activation, and immune-mediated tissue damage.

Finally, this review examines emerging therapeutic targets with potential relevance for intervention, to refine treatment strategies, mitigate cardiovascular adverse effects, and enhance both quality of life and long-term outcomes in affected children. This review integrates these mechanisms within a cohesive, pediatric-specific conceptual framework and highlights actionable cardioprotective targets across therapeutic modalities.