FOS 和 JUN 家族成员及免疫细胞浸润对卵巢癌患者生存的预后相关性

Using the KM Plotter algorithm, Kaplan-Meier statistics were applied to calculate survival times of 373 patients with ovarian carcinoma from The Cancer Genome Atlas (TCGA). Expression of AP-1 dimer components ( FOS, FOSB, FOSL1, FOSL2, JUN, JUNB , and JUND ) was based on RNA sequencing. To estimate immune response, increased or decreased tumor infiltration of immune cells was assessed.

High expression of JUNB alone or in combination with FOSB, FOSL1 , or FOSL2 (but not with JUN, JUND , or FOS ) significantly correlated with shorter survival. Hierarchical clustering of the survival analyses revealed that JUNB (alone or together with FOSB, FOSL1 , or FOSL2 ), combined with decreased counts of CD8+ cytotoxic T cells, regulatory T cells, or natural killer cells, correlated with shorter survival. Conversely, increased tumor infiltration with type 2 T helper cells or basophilic granulocytes and JUNB-containing AP-1 dimers also correlated with poor overall survival.

Specific combinations of AP-1 dimer components were of prognostic value for shorter overall survival and were associated with immune cell infiltration linked to "cold" phenotypes non-responsive to immunotherapy. JUNB-containing AP-1 dimers may promote immune evasion and tumor-progressing immune responses. Our results may help identify high-risk patients and support the evaluation of JUNB-containing AP-1 dimers as prognostic factors for ovarian carcinoma.