CAR-T(CAR-T)细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Review of advances in CAR-T therapies in malignant hematology.
Review of advances in CAR-T therapies in malignant hematology.
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在恶性血液病领域,免疫细胞效应治疗已取得诸多进展。这篇综述文章探讨了促使CAR-T 细胞疗法获批用于血液系统恶性肿瘤的关键研究,并重点介绍了现有的相关长期数据和真实世界数据。文章还审视了耐药机制以及克服这些机制的潜在新型疗法。
There have been numerous advancements in immune cell effector therapies in the malignant hematology space. This review article explores the pivotal studies that led to the approval of chimeric antigen receptor T-cell (CAR-T) therapies for hematologic malignancies and highlights available associated long-term and real-world data. It also examines the mechanisms of resistance and potential novel therapies to overcome these mechanisms.
在 PubMed 查看 → 出版商原文(DOI) 全文 PDF(PMC)· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
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