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恶性血液病 CAR-T 治疗进展综述

英文原题:Review of advances in CAR-T therapies in malignant hematology.

查看英文原题

Review of advances in CAR-T therapies in malignant hematology.

PubMed 2026/03/17(内容时间) Front Oncol Q2 · IF 3.4(JCR 2025)

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中文摘要

在恶性血液病领域,免疫细胞效应治疗已取得诸多进展。这篇综述文章探讨了促使CAR-T 细胞疗法获批用于血液系统恶性肿瘤的关键研究,并重点介绍了现有的相关长期数据和真实世界数据。文章还审视了耐药机制以及克服这些机制的潜在新型疗法。

展开英文摘要原文

There have been numerous advancements in immune cell effector therapies in the malignant hematology space. This review article explores the pivotal studies that led to the approval of chimeric antigen receptor T-cell (CAR-T) therapies for hematologic malignancies and highlights available associated long-term and real-world data. It also examines the mechanisms of resistance and potential novel therapies to overcome these mechanisms.

论文信息

作者
Amirmokhtari N、Lutfi F
单位
Hematologic malignancies and cellular therapy, The University of Kansas Hospital - Westwood Medical Pavilion, Westwood, KS, United States.United States
文献类型
综述
期刊
Frontiers in oncology2026
原文标识
PubMed 41924606 · DOI 10.3389/fonc.2026.1768614