ILC2 的过继转移揭示胶质母细胞瘤中的肿瘤归巢：一项概念验证研究

Bone marrow-derived ILC2s from C57BL/6 mice were fluorescently labeled and intravenously transferred into hosts bearing orthotopic, luciferase-expressing GL261 glioblastoma tumors. Immune cell localization was assessed using fluorescence imaging and flow cytometric analyses of brain, tumor tissue, meninges, and peripheral organs.

Systemically administered ILC2s accessed the CNS and were detected within intracranial glioblastoma tumors and meninges. Transferred ILC2s localized to tumor tissue and meninges and were also identified in peripheral organs, demonstrating effective trafficking and tumor homing in an immunocompetent model. No measurable reduction in tumor growth was observed.

These findings establish a proof-of-concept that adoptively transferred ILC2s can access and localize within glioblastoma in vivo . While not associated with tumor growth inhibition in this study, the results provide foundational insight into innate immune cell trafficking to central nervous system tumors and support further investigation into the immunomodulatory potential of ILC2s in GBM.