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多能之路通向免疫工程

英文原题:A Pluripotent Road to Immunoengineering.

查看英文原题

A Pluripotent Road to Immunoengineering.

PubMed 2023/03/31(内容时间) Nat Rev Bioeng Q1 · IF 42.7(JCR 2025)

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中文摘要

过继性免疫治疗,尤其是CAR-T 细胞,在过去十年中治疗血液系统恶性肿瘤取得了相当大的成功。然而,患者来源细胞工程化的变异性、时间投入和高成本限制了其应用。人类多能干细胞可能为这些问题提供一种现成的、更便宜且可扩展的解决方案。

展开英文摘要原文

Adoptive immunotherapy, particularly chimeric antigen receptor T cells, has achieved considerable success in treating hematologic malignancies over the past decade. However, variability, time commitment and high cost for engineering patient-derived cells have limited their application. Human pluripotent stem cells could provide an off-the-shelf, cheaper and scalable solution to these issues.

论文信息

作者
Chang Y、Deng Q、Bao X
单位
Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN, US.United States
期刊
Nature reviews bioengineering2023 Aug
原文标识
PubMed 41789189 · DOI 10.1038/s44222-023-00056-2