CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
模块化联盟：益生菌与巨噬细胞在胶质母细胞瘤中的汇聚
英文原题：A modular alliance: Probiotics and macrophages converge on glioblastoma.
查看英文原题
A modular alliance: Probiotics and macrophages converge on glioblastoma.
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中文摘要
胶质母细胞瘤的抗原异质性和免疫抑制微环境限制了治疗效果。在本期，Zhang等人提出了一种多模式平台，其中工程化益生菌将多种肿瘤细胞“涂上”共同标签，使通用型嵌合抗原受体（CAR）巨噬细胞能够进行攻击。这一优雅而复杂的策略为适应性免疫治疗提供了新的蓝图。
展开英文摘要原文
Glioblastoma's antigenic heterogeneity and immunosuppressive microenvironment limit therapeutic efficacy. In this issue, Zhang et al. present a multimodal platform where engineered probiotics "paint" diverse tumor cells with a common tag, enabling universal chimeric antigen receptor (CAR) macrophages to attack. This elegant yet complex strategy offers a new blueprint for adaptable immunotherapy.
论文信息
- 作者
- Zhao J、Chen J
- 第一作者单位
- Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102206, China; Chinese Institute for Brain Research, Beijing, Beijing 102206, China; Changping Laboratory, Beijing 102206, China.China
- 通讯作者单位
- Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102206, China; Chinese Institute for Brain Research, Beijing, Beijing 102206, China; Changping Laboratory, Beijing 102206, China. Electronic address: chenjian@cibr.ac.cn.China
- 文献类型
- 评论
- 期刊
- Cell host & microbe2026 Feb 11
- 原文标识
- PubMed 41679284 · DOI 10.1016/j.chom.2026.01.005