CAR-T(CAR-T)细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Development of an Electronic Learning Module for CAR-T Education in Canadian Hematology Residents.
Development of an Electronic Learning Module for CAR-T Education in Canadian Hematology Residents.
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CAR-T 细胞疗法是一种新型癌症治疗方式,涉及特殊治疗注意事项和相关毒性,因此仅在部分医院开展。由此,血液科培训医师接触CAR-T 管理的机会不一。本研究旨在系统开发一项全国性电子学习模块(ELM),促进加拿大血液科培训医师接受CAR-T 教育。首先通过问卷开展需求评估。参与者认为进一步接受CAR-T 治疗教育具有中等至显著获益,并指出了重点教育内容和ELM的优先事项。根据这些数据,并结合CAR-T 领域专家意见,研究者使用Articulate 360平台开发ELM。随后开展半结构式焦点小组对初稿进行试用,并通过定性主题分析归纳正面和负面反馈中的一致主题。研究团队据此反复修订,最终ELM已作为开放获取资源在线发布。研究结果表明,成功开发了CAR-T 电子学习资源,以填补这一新型癌症治疗方式的教育缺口。未来将定量评估ELM的教育效果。
Chimeric antigen receptor T-cell (CAR-T) therapy is a novel cancer treatment modality associated with unique treatment considerations and associated toxicities and therefore is administered at select hospitals. As a result, hematology trainees have variable exposure to CAR-T management. The purpose of this study was to systematically develop a national electronic learning module (ELM) to facilitate CAR-T education among Canadian hematology trainees. First, a survey-based needs assessment was conducted. Participants indicated moderate to significant benefit from further education on CAR-T therapy. They also identified key content areas of educational need and key priorities for a CAR-T ELM.
Based on this data, an ELM was developed using the Articulate 360 platform, with input from CAR-T content experts. Semi-structured focus groups were then conducted to pilot the draft ELM, and qualitative thematic analysis identified consistent themes in positive and negative feedback.
The ELM was further iteratively revised based on this feedback, and the final ELM product has been made available online as an open-access resource. The results of this study demonstrate the successful development of a CAR-T e-learning resource to fulfill an educational gap for a novel cancer therapy. Future steps include quantitative evaluation of the educational efficacy of the ELM.
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