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Blinatumomab 无应答与 B 细胞 ALL 患者接受 brexucabtagene autoleucel 治疗后生存率较差相关

英文原题:Blinatumomab nonresponse correlates with poor survival after brexucabtagene autoleucel in B-cell ALL.

查看英文原题

Blinatumomab nonresponse correlates with poor survival after brexucabtagene autoleucel in B-cell ALL.

PubMed 2026/04/23(内容时间) Blood Q1 · IF 23.9(JCR 2025)

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中文摘要

在一项针对复发/难治性B细胞急性淋巴细胞白血病的brexucabtagene autoleucel接受者(N = 278)的真实世界分析中,对先前blinatumomab无应答与随后CAR-T 细胞治疗结局显著更差相关。

展开英文摘要原文

In a real-world analysis of brexucabtagene autoleucel recipients with relapsed/refractory B-cell acute lymphoblastic leukemia (N = 278), lack of response to prior blinatumomab correlates with significantly worse following chimeric antigen receptor T-cell therapy outcomes.

论文信息

作者
Srinagesh HK、Gupta V、Zhang A、Grunwald M、Connor M、Kota VK、Boccucci J、Ulrickson M
第一作者单位
Division of Hematology/Oncology, Stanford University School of Medicine, Palo Alto, CA.United States
通讯作者单位
Division of Hematology and Oncology, UH Seidman Cancer Center, University Hospitals, Cleveland, OH.United States
期刊
Blood2026 Apr 23
原文标识
PubMed 41643192 · DOI 10.1182/blood.2025031734