CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
贾坎德邦一家三级医疗中心对乳腺癌新辅助治疗后组织形态学变化的评估
英文原题：Evaluation of histomorphological changes in breast cancer following neoadjuvant therapy at a tertiary care centre, Jharkhand.
查看英文原题
Evaluation of histomorphological changes in breast cancer following neoadjuvant therapy at a tertiary care centre, Jharkhand.
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中文摘要
乳腺癌仍是全球女性癌症相关死亡的主要原因，治疗反应预测一直是一项持续存在的挑战。新辅助治疗（NAT）可实现肿瘤降期并评估组织病理学反应。在这项纳入125例患者的前瞻性研究中，NAT导致肿瘤细胞密度显著降低（82.4% ± 12.3%降至31.7% ± 18.9%，p < 0.001），纤维化增加（15.2% ± 8.7%升至48.6% ± 15.4%，p < 0.001）。32%的患者达到病理完全缓解（pCR），三阴性（42.1%）和HER2阳性（38.5%）亚型中发生率更高。NAT后高TIL（肿瘤浸润淋巴细胞）与pCR强相关（r = 0.67，p < 0.001）。因此，我们表明NAT诱导显著的组织形态学变化，这些变化可作为治疗反应和患者预后的关键预后指标。
展开英文摘要原文
Breast cancer remains a major cause of cancer-related mortality among women worldwide, with treatment response prediction posing a persistent challenge. Neoadjuvant therapy (NAT) offers tumor downstaging and assessment of histopathological response. In this prospective study of 125 patients, NAT led to a significant reduction in tumor cellularity (82. 4% ± 12.
3% to 31. 7% ± 18. 9%, p < 0. 001) and increased fibrosis (15. 2% ± 8. 7% to 48. 6% ± 15. 4%, p < 0. 001). Pathological complete response (pCR) occurred in 32% of patients, with higher rates in triple-negative (42. 1%) and HER2-positive (38. 5%) subtypes. High post-NAT tumor-infiltrating lymphocytes correlated strongly with pCR (r = 0. 67, p < 0. 001).
Thus, we show that NAT induces significant histomorphological changes, which can serve as key prognostic indicators for therapeutic response and patient outcomes.
论文信息
- 作者
- Ashok C、Kumar A、Priya A、Banerjee S、Ansari A、Mahto S
- 单位
- Department of Pathology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.India
- 期刊
- Bioinformation2025
- 原文标识
- PubMed 41623794 · DOI 10.6026/973206300213770
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