CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
外泌体处理后癌细胞依赖性的衰老样细胞群增加：细胞外基质与细胞糖萼的作用
英文原题：Cancer cell-dependent increase in senescence-like populations following exosome treatment: The role of extracellular matrix and cellular glycocalyx.
查看英文原题
Cancer cell-dependent increase in senescence-like populations following exosome treatment: The role of extracellular matrix and cellular glycocalyx.
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中文摘要
我们怀着浓厚兴趣阅读了Ababneh等人的研究。该研究显示，诱导型间充质干细胞来源外泌体可通过诱导一种无凋亡的衰老样状态，产生更强且更持久的抗增殖效应。作者所得结果凸显了在周围组织诱导衰老漂移的影响特点。基于这些发现，细胞外基质和细胞糖萼特性在人类肿瘤治疗应答中的作用仍未得到研究。这些细胞外屏障似乎是有效癌症治疗的重要障碍，尤其在利用肿瘤微环境独特特性治疗免疫治疗耐药癌症时更是如此。
展开英文摘要原文
We read with the great interest the study by Ababneh et al in which induced mesenchymal stem cell-derived exosomes were shown to exhibit a stronger and more sustained anti-proliferative effect by inducing a senescence-like state without apoptosis. The results obtained by the authors highlight the features of the effects of senescent drift induction in surrounding tissues.
In the light of these findings, the role of the properties of extracellular matrix and cellular glycocalyx in responses of human tumors to therapy remain uninvestigated. These extracellular barriers appear to be significant obstacles to effective cancer therapy, especially in relation to the use of unique properties of tumor microenvironment for the immunotherapy-resistant cancer treatment.
论文信息
- 作者
- Klabukov ID、Kisel A、Yatsenko E、Sulina Y、Baranovskii DS
- 第一作者单位
- Department of Regenerative Medicine, National Medical Research Radiological Center, Obninsk 249036, Kaluzhskaya Oblast', Russia.Russia
- 通讯作者单位
- Obninsk Institute for Nuclear Power Engineering, National Research Nuclear University MEPhI, Obninsk 249033, Kaluzhskaya Oblast', Russia. ilya.klabukov@gmail.com.Russia
- 文献类型
- 读者来信
- 期刊
- World journal of stem cells2026 Jan 26
- 原文标识
- PubMed 41608658 · DOI 10.4252/wjsc.v18.i1.115655
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