RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Resveratrol for Cancer Treatment: Effects on Metabolism and Immune Cells.
Resveratrol for Cancer Treatment: Effects on Metabolism and Immune Cells.
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白藜芦醇是一种存在于植物中的天然多酚,因其抗肿瘤潜力而受到广泛研究关注。随着对肿瘤微环境和代谢重编程的持续研究,白藜芦醇在肿瘤细胞代谢和免疫细胞功能中的作用日益受到重视。近期研究表明,白藜芦醇通过抑制糖酵解和脂肪酸生成等代谢过程,破坏肿瘤细胞代谢,阻止肿瘤细胞生长和转移。此外,白藜芦醇调节T细胞、巨噬细胞和NK 细胞等免疫细胞,增强抗肿瘤免疫应答。本文报告了白藜芦醇用于肿瘤治疗的最新研究进展。具体而言,我们聚焦于其对肿瘤代谢和免疫微环境的调节作用,并讨论其与一种新治疗策略联合应用的潜力。
Resveratrol is a natural polyphenol found in plants that has attracted significant research attention for its antitumor potential. With the continuing research on the tumor microenvironment and metabolic reprogramming, the roles of resveratrol in tumor cell metabolism and immune cell function have gained increasing attention. Recent studies have shown that resveratrol disrupts tumor cell metabolism and prevents tumor cell growth and metastasis by inhibiting metabolic processes such as glycolysis and fatty acid production.
Furthermore, resveratrol regulates immune cells such as T cells, macrophages, and natural killer cells and enhances antitumor immune responses. In this article, we report the recent research progress on the use of resveratrol for tumor therapy. Specifically, we focus on its regulatory effect on tumor metabolism and the immune microenvironment and discuss its potential in combination with a new therapeutic strategy.
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