RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
人多能干细胞来源的固有免疫与适应性免疫细胞用于肿瘤免疫治疗
英文原题：Human pluripotent stem cell-derived innate and adaptive immune cells for cancer immunotherapy.
查看英文原题
Human pluripotent stem cell-derived innate and adaptive immune cells for cancer immunotherapy.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
异体细胞疗法在癌症免疫治疗中前景广阔，但面临规模化、免疫排斥、移植物抗宿主病和毒性等挑战。人多能干细胞（hPSC），包括胚胎干细胞和诱导多能干细胞（iPSC），提供了可规模化、适应性强的平台，有望克服这些局限。hPSC可作为取之不尽的免疫细胞来源，并能在单细胞水平进行基因改造，以增强抗肿瘤活性、降低免疫原性。近期iPSC来源自然杀伤（NK）细胞、T细胞和巨噬细胞制备进展，为更安全、更有效的免疫疗法打开了道路。本综述考察利用hPSC来源免疫细胞增强癌症治疗的进展、挑战和未来方向，并探讨其克服异体治疗障碍的潜力。
展开英文摘要原文
Allogeneic cell-based therapies hold great promise for cancer immunotherapy but face challenges like scalability, immune rejection, graft-versus-host disease, and toxicities. Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells (iPSCs), offer a scalable and adaptable platform to address these limitations.
hPSCs provide an inexhaustible source of immune cells that can be genetically modified at the single-cell level to enhance anti-tumor activity and reduce immunogenicity. Recent advancements in generating iPSC-derived natural killer (NK) cells, T cells, and macrophages are opening the door to safer and more effective immunotherapies. This review examines the progress, challenges, and future directions in utilizing hPSC-derived immune cells to enhance cancer treatment and overcome barriers in allogeneic therapy.
论文信息
- 作者
- Shah Z、Tian L、Caligiuri MA、Kaufman DS、Yu J
- 第一作者单位
- Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA 91010, USA; Hematologic Malignancies Research Institute, City of Hope National Medical Center, Los Angeles, CA 91010, USA.United States
- 通讯作者单位
- Division of Hematology & Oncology, Department of Medicine, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA; The Clemons Family Center for Transformative Cancer Research, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: jianhuay@uci.edu.United States
- 文献类型
- 综述 · 美国 NIH 资助研究 · 美国政府（非公共卫生署）资助研究
- 期刊
- Cell stem cell2026 Feb 5
- 原文标识
- PubMed 41512874 · DOI 10.1016/j.stem.2025.12.017
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →