CD24 与突变型 p53：前列腺癌进展中的新兴治疗靶点

Through a systematic search of the PubMed, Web of Science, and Embase databases (2015-2025), using the following structured search terms: (CD24 OR "CD24 antigen") AND ("prostate cancer" OR "prostatic neoplasms") AND ("mutant p53" OR "TP53 mutation") AND ("targeted therapy" OR immunotherapy), relevant studies were identified and screened according to PRISMA guidelines.

CD24 overexpression was significantly associated with high Gleason scores, metastasis, and poor prognosis. Mechanistically, CD24 promotes tumor progression by destabilizing p53 through the disruption of ARF-NPM interactions and by synergizing with mutant p53. Preclinical studies indicate that therapies targeting CD24, such as CAR-T cells and nanoparticle-based drug delivery systems, demonstrate potent anti-tumor effects. DISCUSSION: The CD24-p53 axis is amplified in mCRPC and interacts with androgen receptor signaling, while tumor microenvironment factors further enhance treatment resistance.

CD24 and mutant p53 represent promising therapeutic targets in metastatic castration-resistant prostate cancer (mCRPC). Translating these targeting strategies into clinical practice may help overcome current therapeutic challenges and improve patient outcomes.