免疫检查点阻断通过扩增效应 CD8⁺ T 细胞克隆增强淋巴细胞清除性化疗诱导的抗肿瘤免疫
Immune Checkpoint Blockade Augments Lymphodepleting Chemotherapy-Induced Antitumor Immunity by Expanding Effector CD8+ T-cell Clones.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
可切除皮肤黑色素瘤辅助与新辅助治疗的最新进展
英文原题：Updates in adjuvant and neoadjuvant therapies for resectable cutaneous melanoma.
查看英文原题
Updates in adjuvant and neoadjuvant therapies for resectable cutaneous melanoma.
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中文摘要
在过去15年中，免疫检查点抑制剂和丝裂原活化蛋白激酶靶向治疗彻底改变了黑色素瘤的治疗。然而，部分患者仍面临疾病复发的高风险。因此，需要降低复发风险的策略。近期试验评估了在III/IV期黑色素瘤切除术前使用免疫检查点抑制剂（新辅助治疗）与术后常规使用这些药物（辅助治疗）的比较。此外，检查点抑制剂目前正在IIb/IIc期黑色素瘤中进行研究。在此，我们综述了近期随机临床试验，这些试验提示新辅助使用检查点抑制剂（术前）以及在较早（II期）黑色素瘤中使用检查点抑制剂可能改善结局。
展开英文摘要原文
Over the last 15 years, treatment of melanoma has been revolutionized using immune checkpoint inhibitors and mitogen-activated protein kinase-targeted therapies.
However, some patients are at high risk of disease recurrence.
Therefore, strategies to reduce the risk of recurrence are needed. Recent trials have evaluated the use of immune checkpoint inhibitors prior to stage III/IV melanoma resection (neoadjuvant treatment) in comparison to conventional use of these drugs after surgery (adjuvant treatment).
In addition, checkpoint inhibitors are now being studied for stage IIb/IIc melanoma.
Herein, we review recent randomized clinical trials that suggest that neoadjuvant use of checkpoint inhibitors (prior to surgery) and use of checkpoint inhibitors in earlier (stage II) melanoma may improve outcomes.
论文信息
- 作者
- Hadfield MJ、Muzumdar S、Sullivan RJ、Katz S、Grant-Kels JM
- 第一作者单位
- Department of Medicine, Division of Hematology/Oncology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island.United States
- 通讯作者单位
- Department of Dermatology, University of Connecticut School of Medicine, Farmington, Connecticut; Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida. Electronic address: grant@uchc.edu.United States
- 文献类型
- 综述
- 期刊
- Journal of the American Academy of Dermatology2026 Apr
- 原文标识
- PubMed 41453433 · DOI 10.1016/j.jaad.2025.12.068