CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
下一代 CAR-T 细胞设计：利用肿瘤特征提高疗效
英文原题：Next-generation CAR-T cells design: leveraging tumor features for enhanced efficacy.
查看英文原题
Next-generation CAR-T cells design: leveraging tumor features for enhanced efficacy.
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中文摘要
基因工程和合成生物学的进步显著加速了CAR-T（CAR-T）细胞疗法在癌症治疗中的开发和应用。尽管取得了实质性进展，实体瘤的治疗仍然具有挑战性，临床结局欠佳且存在显著未满足的需求。为应对这些持续存在的挑战，目前正在做出大量努力以提高CAR-T 细胞疗法的安全性、疗效和整体适用性。本综述概述了阻碍CAR-T 疗效的关键肿瘤特征，重点关注肿瘤内在因素和微环境的影响。随后，我们全面概述了有前景的下一代CAR-T 设计，并讨论了旨在改善抗原识别、功能适应性和抗肿瘤反应的联合策略，从而扩大CAR-T 细胞在实体瘤环境中的治疗影响。
展开英文摘要原文
Advancements in genetic engineering and synthetic biology have markedly accelerated the development and application of chimeric antigen receptor T (CAR-T) cell therapy for cancer treatment. Despite substantial progress, the treatment of solid tumors remains challenging, with suboptimal clinical outcomes and significant unmet needs.
To address these ongoing challenges, considerable efforts are being made to enhance the safety, efficacy, and overall applicability of CAR-T cells therapy. This review outlines the key tumor features that impede CAR-T efficacy, focusing on intrinsic tumor factors and the influence of the microenvironment.
We then provide a comprehensive overview of the promising next-generation CAR-T designs and discuss the combinatorial approaches aimed at improving antigen recognition, functional adaptability, and antitumor response, thereby expanding the therapeutic impact of CAR-T cells in solid-tumor settings.
论文信息
- 作者
- Lei Y、Liu N、Qin D、Liu M、Wang Y
- 第一作者单位
- Division of Thoracic Tumor Multimodality Treatment, Cancer Center, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.China
- 通讯作者单位
- Division of Thoracic Tumor Multimodality Treatment, Cancer Center, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. wangys@scu.edu.cn.China
- 文献类型
- 综述
- 期刊
- Molecular cancer2025 Dec 19
- 原文标识
- PubMed 41419929 · DOI 10.1186/s12943-025-02515-3
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