CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
靶向实体瘤治疗中肿瘤相关巨噬细胞与 CAR-T 细胞的动态相互作用
英文原题：Targeting the Dynamics Between TAMs and CAR-T Cells in Solid Tumor Therapies.
查看英文原题
Targeting the Dynamics Between TAMs and CAR-T Cells in Solid Tumor Therapies.
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中文摘要
尽管 CAR-T 细胞疗法已改变了血液系统恶性肿瘤患者的治疗结局，但由于 TAM 免疫抑制，实体瘤治疗中仍存在现有障碍。本综述探讨了他人关于肿瘤微环境中 M2 样免疫抑制性 TAMs 与 CAR-T 细胞之间相互作用的研究。描述了 TAMs 通过细胞因子分泌、免疫检查点、代谢物以及有害的翻译后修饰介导损害 CAR-T 细胞效应功能的方式。针对这些相互作用设计了新概念治疗策略，以提高 CAR-T 细胞在实体瘤中的疗效。本综述着重于对抗 TAM 免疫抑制的新策略，旨在重塑对 CAR-T 疗法在实体瘤中实用性和有效性的看法，并因此拓展这一极具前景的治疗方法的可及范围。
展开英文摘要原文
Although CAR T-cell therapy has transformed treatment outcomes for patients with haematological malignancies, the existing barriers in solid tumors treatment remain due to TAM immunosuppression. This review explores the work of others on the interplay between M2-like immunosuppressive TAMs and CAR-T cells in the tumor microenvironment. The ways TAMs impair the effector functions of CAR-T cells are described mediated by secretion of cytokines, immune checkpoints, metabolites, and detrimental post-translational modification.
New concept therapeutic approaches are designed to these interactions for improving the efficacy of CAR-T cells in solid tumors. With an emphasis on novel strategies to counteract TAM immunosuppression, this review aims to reshape the perspective on the utility and effectiveness of CAR-T therapy in solid tumors and, consequently, extend the reach of a highly promising therapeutic approach.
论文信息
- 作者
- Zhang X、Zheng H、Liu ZC、Luo LJ、Dong X、Cui XG、Wu YW、Chen L
- 单位
- School of Medicine, Shanghai University, Shanghai, 200444, China.China
- 文献类型
- 综述
- 期刊
- Advanced science (Weinheim, Baden-Wurttemberg, Germany)2026 Jan
- 原文标识
- PubMed 41271577 · DOI 10.1002/advs.202515700
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