CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
实体瘤 CAR-T 疗法的新进展：2025 ASCO 年会最新临床试验更新
英文原题：Emerging advances in CAR-T therapy for solid tumors: latest clinical trial updates from 2025 ASCO annual meeting.
查看英文原题
Emerging advances in CAR-T therapy for solid tumors: latest clinical trial updates from 2025 ASCO annual meeting.
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中文摘要
CAR-T 细胞疗法已在血液系统恶性肿瘤中展现出变革性影响，并为多线治疗失败的实体瘤患者带来新希望提供了一种有前景的策略。然而，CAR-T 疗法在实体瘤中的临床应用仍面临挑战，包括肿瘤异质性、免疫抑制性肿瘤微环境以及安全性问题。这些障碍意味着 CAR-T 疗法已成为当代临床研究的焦点和关键趋势。美国临床肿瘤学会（ASCO）年会是将突破性临床数据公之于众的首要平台。在这篇综述中，我们重点介绍 2025 ASCO 年会上公布的 CAR-T 疗法用于实体瘤的主要 I 期临床试验进展。
展开英文摘要原文
Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated a transformative impact in hematologic malignancies and offers a promising strategy to offer new hope for patients with solid tumors who have failed multiple lines of treatment. The clinical application of CAR-T therapy in solid tumors, however, still has challenges, including tumor heterogeneity, an immunosuppressive tumor microenvironment, and safety concerns.
These hurdles have mean that CAR-T therapy has become both a focal point and a pivotal trend in contemporary clinical research. The American Society of Clinical Oncology (ASCO) Annual Meeting serves as a premier venue for unveiling groundbreaking clinical data. In this review, we highlight the main phase I clinical trial advances in CAR-T therapy for solid tumors presented at the 2025 ASCO Meeting.
论文信息
- 作者
- Li W、Zhao D、Chen M、Yan X
- 第一作者单位
- Department of Hematology, The First Hospital of China Medical University, 155N. Nanjing Street, Shenyang, 110001, Liaoning, China.China
- 通讯作者单位
- Department of Hematology, The First Hospital of China Medical University, 155N. Nanjing Street, Shenyang, 110001, Liaoning, China. yanxiaojing_pp@hotmail.com.China
- 文献类型
- 综述 · 读者来信
- 期刊
- Journal of hematology & oncology2025 Nov 19
- 原文标识
- PubMed 41257786 · DOI 10.1186/s13045-025-01760-9
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