通过靶向肿瘤相关巨噬细胞的嵌合受体工程化溶瘤病毒重振内源性抗肿瘤免疫
Rejuvenating endogenous antitumor immunity via a chimeric receptor-engineered oncolytic virus targeting tumor-associated macrophages.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
头颈部肿瘤的免疫治疗和靶向治疗考虑
英文原题：Immunotherapy and Targeted Therapy Considerations in Head and Neck Oncology.
查看英文原题
Immunotherapy and Targeted Therapy Considerations in Head and Neck Oncology.
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中文摘要
头颈部肿瘤的免疫治疗引入了新的肿瘤反应模式和免疫相关毒性，这些可模拟疾病进展并对传统影像评估构成挑战。准确解读需要深入理解免疫检查点抑制剂、CAR-T 细胞疗法和溶瘤病毒治疗，同时识别非典型反应，如假性进展、超进展、分离反应和持久反应。采用改良影像学标准如iRECIST和imPERCIST可提高诊断准确性。放射科医生在识别跨器官系统的免疫相关不良事件、指导适当管理以及在治疗有效时支持继续治疗方面发挥着至关重要的作用。
展开英文摘要原文
Immunotherapy in head and neck cancer introduces novel tumor response patterns and immune-related toxicities that can mimic disease progression and challenge traditional imaging assessment. Accurate interpretation requires in-depth understanding of immune checkpoint inhibitors, chimeric antigen receptor-T cell therapy, and oncolytic virus treatments, along with recognition of atypical responses such as pseudoprogression, hyperprogression, dissociated response, and durable response.
Incorporating modified imaging criteria like iRECIST and imPERCIST enhances diagnostic accuracy. Radiologists play a vital role in identifying immune-related adverse events across organ systems, guiding appropriate management, and supporting continued treatment when effective.
论文信息
- 作者
- Dagher R、Khalaf A、Ferrarotto R、Learned KO
- 第一作者单位
- Department of Neuroradiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX 77030, USA. Electronic address: rich.dagh@gmail.com.United States
- 通讯作者单位
- Department of Neuroradiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX 77030, USA. Electronic address: KOLearned@mdanderson.org.United States
- 文献类型
- 综述
- 期刊
- Radiologic clinics of North America2026 Jan
- 原文标识
- PubMed 41233057 · DOI 10.1016/j.rcl.2025.07.002