CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
超声辅助在肿瘤免疫治疗中的应用研究进展
英文原题：Research Progress on the Application of Ultrasound Assistance in Tumor Immunotherapy.
查看英文原题
Research Progress on the Application of Ultrasound Assistance in Tumor Immunotherapy.
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中文摘要
近年来，超声（US）辅助肿瘤免疫治疗因其深层穿透性以及非侵入性和非电离辐射特性而受到广泛关注。在本综述中，我们简要阐述了US辅助抗肿瘤免疫治疗的机制。内容包括：US的机械效应、热效应和空化效应，声动力疗法，US联合程序性细胞死亡蛋白1/程序性细胞死亡1配体1抗体，US增强CAR-T 细胞免疫治疗，细胞焦亡与US，US联合放疗，US联合糖酵解抑制，以及利用各种US调控的信号通路增强肿瘤免疫。本综述对US在肿瘤免疫治疗中辅助作用的机制和角色提供了广泛的概述。
展开英文摘要原文
Recently, ultrasound (US)-assisted tumor immunotherapy has attracted widespread attention due to its deep penetration as well as its non-invasive and non-ionizing radiation properties. In this review, we briefly elucidated the mechanisms of anti-tumor immunotherapy assisted by the US.
The contents include the following: the mechanical effects, thermal effects, and cavitation effects of US, sonodynamic therapy, US combined with programmed cell death protein 1 / programmed cell death 1 ligand 1 antibodies, US-enhanced chimeric antigen receptor T cell immunotherapy, cell pyroptosis and US, US combined with radiotherapy, US combined with glycolysis inhibition, and the use of various US-modulated signaling pathways to enhance tumor immunity.
This review provides a broad overview of the mechanisms and roles of US assistance in tumor immunotherapy.
论文信息
- 作者
- Fan LY、Yu H、Cui LW、Shen ZY
- 单位
- Department of Radiology, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, Nantong, China.China
- 文献类型
- 综述
- 期刊
- Current medicinal chemistry2026
- 原文标识
- PubMed 41208064 · DOI 10.2174/0109298673337725250108091641