pH 敏感黏土纳米材料用于增强实体瘤免疫治疗的最新进展

The tumor microenvironment is a formidable barrier, complicated by physicochemical malice to the immune system, limiting the clinical efficacy of immunotherapy, particularly CAR-T, in solid tumor management. Various strategies have been proposed and examined to enhance immunotherapy, while the aberrant and hostile physicochemical microenvironment (such as low pH, hypoxia, high ROS/RNS and deficient nutrient ions) is always a key and general challenge that must be addressed in order to improve the efficacy of CAR-T and immune checkpoint blockage for solid tumor treatment.

Fortunately, recent investigations demonstrate that some clay nanomaterials are able to correct aberrant pH and O 2 levels in the tumor microenvironment and recruit more anti-tumor immune cells into tumor tissues, breaking the immunosuppressive barrier and inhibiting tumor growth in vivo .

This minireview briefly summarizes the timely progress in restoring the physicochemical homeostasis in tumor tissues to convert the 'cold' immune microenvironment to a 'hot' one for enhanced immunotherapy of solid tumors and further provides my personal perspectives for future research.