CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗儿童和年轻成人 B 细胞急性淋巴细胞白血病的机遇与挑战：Westhafen 洲际小组的综述与建议
英文原题：Opportunities and Challenges With CAR T-cell Treatment of Children and Young Adults With B-Cell Acute Lymphoblastic Leukemia: Review and Recommendations From the Westhafen Intercontinental Group.
查看英文原题
Opportunities and Challenges With CAR T-cell Treatment of Children and Young Adults With B-Cell Acute Lymphoblastic Leukemia: Review and Recommendations From the Westhafen Intercontinental Group.
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中文摘要
靶向儿童B细胞前体急性淋巴细胞白血病（B-ALL）的CAR-T 细胞改变了复发难治性B-ALL的治疗模式。本文由Westhafen洲际工作组提供该领域的全面综述和建议。该工作组由国际柏林-法兰克福-明斯特（iBFM）干细胞移植委员会、国际血液和骨髓移植研究中心（CIBMTR）儿童癌症工作委员会、儿童肿瘤组（COG）细胞治疗委员会、欧洲血液和骨髓移植学会（EBMT）儿童疾病工作组（PDWP）及儿童移植与细胞治疗联盟（PTCTC）的专家组成。本文考察儿童B-ALL中CAR-T 疗法的现状，评估CAR-T 在治疗流程中的现有及新兴整合方式，并讨论克服现有挑战的新兴策略。
展开英文摘要原文
Chimeric antigen-receptor T-cells (CAR T-cells) targeted at pediatric B-cell precursor acute lymphoblastic leukemia (B-ALL) have changed the paradigm for treatment of relapsed and refractory B-ALL.
We present a comprehensive review and recommendations approaching this topic from the Westhafen Intercontinental Group, which is comprised of leaders from the International Berlin Frankfurt, Muenster (iBFM) Stem Cell Transplantation Committee, the Center for International Blood and Marrow Transplant Research (CIBMTR) Pediatric Cancer Working Committee, the Children's Oncology Group (COG) Cellular Therapy Committee, the Pediatric Diseases Working Party (PDWP) of the European Society for Bone and Marrow Transplantation (EBMT) and the Pediatric Transplantation and Cellular Therapy Consortium (PTCTC).
In this paper we examine the current state of CAR T-cell therapy in pediatric B-ALL, assess current and emerging integration of CAR T-cells into treatment algorithms, and discuss emerging strategies to overcome existing challenges.
论文信息
- 作者
- Deimundo Roura C、Amrolia P、Ansari M、Bader P、Balduzzi A、Buechner J、Hsieh EM、Myers RM
- 第一作者单位
- Division of Pediatric Hematology and Oncology, Intermountain Primary Children's Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, Utah.
- 通讯作者单位
- Division of Pediatric Hematology and Oncology, Intermountain Primary Children's Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, Utah. Electronic address: michael.pulsipher@hci.utah.edu.
- 文献类型
- 综述
- 期刊
- Transplantation and cellular therapy2026 Mar
- 原文标识
- PubMed 41176033 · DOI 10.1016/j.jtct.2025.10.023