CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗与双特异性抗体的感染并发症——综述
英文原题：Infectious complications of chimeric antigen receptor T cell therapy and bispecific antibodies - A review.
查看英文原题
Infectious complications of chimeric antigen receptor T cell therapy and bispecific antibodies - A review.
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中文摘要
过去十年，嵌合抗原受体（CAR）T细胞疗法改变了血液系统恶性肿瘤的治疗格局，双特异性抗体（BsAb）则是这一患者群体中正在兴起的治疗方法。这些疗法相关的免疫抑制可能导致多种感染并发症。本叙述性综述探讨CAR-T 细胞和BsAb治疗后的细菌、病毒及真菌感染的流行病学、危险因素和预防措施。
展开英文摘要原文
Chimeric antigen receptor (CAR) T cell therapy has shifted the therapeutic landscape of hematological malignancies in the last decade, and bispecific antibodies (BsAb) are an emerging treatment for this patient population. Immunosuppression associated with these therapies can lead to a variety of infectious complications. In this narrative review, we explore the epidemiology, risk factors and prevention of bacterial, viral and fungal infections after CAR T cell and BsAb therapy.
论文信息
- 作者
- Dye B、Gromer D、Maryam B、Siegrist EA、Sassine J
- 第一作者单位
- Infectious Diseases Section, Department of Medicine, College of Medicine, University of Oklahoma, Oklahoma City, OK, USA.United States
- 通讯作者单位
- Infectious Diseases Section, Department of Medicine, College of Medicine, University of Oklahoma, Oklahoma City, OK, USA. Electronic address: joseph-sassine@ouhsc.edu.United States
- 文献类型
- 综述
- 期刊
- The American journal of the medical sciences2026 Feb
- 原文标识
- PubMed 41115502 · DOI 10.1016/j.amjms.2025.10.007