CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
一例血液肿瘤患者中与含芽孢杆菌属清洁喷雾相关的中心静脉导管感染
英文原题：Central line infections in a haematology-oncology patient associated with Bacillus species-containing cleaning spray.
查看英文原题
Central line infections in a haematology-oncology patient associated with Bacillus species-containing cleaning spray.
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中文摘要
血液肿瘤患者因骨髓抑制易发生感染。本文描述一名青少年病例，其既往有前体B细胞急性淋巴细胞白血病复发史，在接受CAR-T 细胞治疗后再次发生白血病，并发生谱系转换为急性髓系白血病。患者曾出现多次芽孢杆菌属引起的中心静脉导管相关血流感染，需要长期使用广谱抗生素、更换中心静脉导管并移除输液港。调查发现，一种市售含芽孢杆菌菌株的“合生元喷雾”可能是污染源。我们呼吁发布公共卫生警示，提醒免疫功能低下者所在环境谨慎使用家用益生菌清洁产品。
展开英文摘要原文
Haemato-oncological patients are susceptible to infections due to aplasia. This article describes an adolescent with a history of a relapse precursor B-cell acute lymphoblastic leukaemia, who experienced a second leukaemia after CAR-T-cell therapy with a lineage switch to acute myeloid leukaemia.
He experienced events of central-line-associated bloodstream infections with Bacillus spp. , requiring long-term broad-spectrum antibiotics, central venous line replacements and removal of a port catheter. A commercially available 'synbiotic spray' containing Bacillus strains was identified as the likely source of contamination.
We advocate for public health warnings regarding the use of household probiotic cleaning products in environments with immunocompromised individuals.
论文信息
- 作者
- Messiaen J、Saegeman V、Depypere M、Cossey V、Renard M、Schuermans A
- 第一作者单位
- Department of Paediatric Oncology - Haematology, University Hospitals Leuven, Leuven, Belgium.Belgium
- 通讯作者单位
- Department of Infection Control, University Hospitals Leuven, Leuven, Belgium; Department of Public Health and Environment, KU Leuven, Leuven, Belgium. Electronic address: annette.schuermans@uzleuven.be.Belgium
- 文献类型
- 病例报告
- 期刊
- The Journal of hospital infection2025 Dec
- 原文标识
- PubMed 41075837 · DOI 10.1016/j.jhin.2025.09.007