CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
原发性纵隔大 B 细胞淋巴瘤中伴 CAR-T 细胞浸润的持续性单侧胸腔积液
英文原题：Persistent Unilateral Pleural Effusion with Chimeric Antigen Receptor T-cell Infiltration in Primary Mediastinal Large B-cell Lymphoma.
查看英文原题
Persistent Unilateral Pleural Effusion with Chimeric Antigen Receptor T-cell Infiltration in Primary Mediastinal Large B-cell Lymphoma.
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中文摘要
嵌合抗原受体（CAR）T细胞治疗后胸腔积液通常为一过性、双侧，并与细胞因子释放综合征相关。本文报告一名34岁男性难治性原发性纵隔大B细胞淋巴瘤患者，其胸膜受累并接受阿基仑赛治疗后，出现CAR-T 细胞浸润相关的持续性单侧大量胸腔积液。流式细胞术证实CAR-T 细胞浸润胸腔积液。皮质类固醇治疗虽使积液暂时改善，但胸腔积液持续数月，最终自行消退。CAR-T 治疗后出现持续性单侧胸腔积液时，医生应考虑CAR-T 细胞浸润；流式细胞术对诊断十分重要，且此类积液可能无需使用皮质类固醇便可自行消退。
展开英文摘要原文
Pleural effusion following chimeric antigen receptor (CAR) T-cell therapy is typically transient, bilateral, and associated with cytokine release syndrome.
We herein report persistent unilateral massive pleural effusion with CAR T-cell infiltration in a 34-year-old man with refractory primary mediastinal large B-cell lymphoma involving pleural lesions treated with axicabtagene ciloleucel. Flow cytometry confirmed CAR T-cell infiltration into the pleural fluid.
Although temporarily improved by corticosteroids, the effusion persisted for several months but eventually resolved spontaneously. Physicians should consider CAR T-cell infiltration in persistent unilateral pleural effusion after CAR T-cell therapy, emphasizing the importance of flow cytometry for the diagnosis and potential spontaneous resolution without corticosteroids.
论文信息
- 作者
- Hayashi H、Sakurai M、Sakamoto M、Shindo T、Koya J、Shiozawa Y、Masuda K、Yamaguchi K
- 单位
- Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan.Japan
- 文献类型
- 病例报告
- 期刊
- Internal medicine (Tokyo, Japan)2026 May 1
- 原文标识
- PubMed 41062320 · DOI 10.2169/internalmedicine.6097-25
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