CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
高级别 B 细胞淋巴瘤患者 CD19 靶向 CAR-T 细胞治疗后的肿瘤炎症相关神经毒性
英文原题：Tumor Inflammation-associated Neurotoxicity Following CD19-targeted Chimeric Antigen Receptor T-cell Therapy in a Patient with High-grade B-cell Lymphoma.
查看英文原题
Tumor Inflammation-associated Neurotoxicity Following CD19-targeted Chimeric Antigen Receptor T-cell Therapy in a Patient with High-grade B-cell Lymphoma.
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中文摘要
一名41岁高级别B细胞淋巴瘤男性患者在一线化疗后发生神经淋巴瘤病（NL）。患者接受CD19嵌合抗原受体（CAR）T细胞疗法（利基仑赛）后，继而出现2型肿瘤炎症相关神经毒性（TIAN），这是一种局部神经事件，有别于免疫效应细胞相关神经毒性综合征。经保守治疗后，患者神经功能恢复并达到完全缓解。本病例提示，CD19 CAR-T 可能有效治疗NL，并强调对累及中枢神经系统的患者应识别TIAN。随着CAR-T 在日本应用日益增加，了解此类并发症对于安全有效治疗至关重要。
展开英文摘要原文
A 41-year-old man with high-grade B-cell lymphoma developed neurolymphomatosis (NL) after frontline chemotherapy. He received CD19 chimeric antigen receptor (CAR) T-cell therapy (lisocabtagene maraleucel) and subsequently developed tumor inflammation-associated neurotoxicity (TIAN) type 2, a localized neurological event distinct from immune effector cell-associated neurotoxicity syndrome.
Conservative treatment resulted in a neurological recovery and complete remission. This case suggests that CD19 CAR T-cell therapy may be effective for NL, and it highlights the importance of recognizing TIAN in patients with central nervous system involvement. As CAR T-cell use has increased in Japan, awareness of such complications is crucial for performing safe and effective treatment.
论文信息
- 作者
- Hino K、Edahiro T、Muta T、Ureshino H、Nakatani S、Nunomura T、Okatani T、Yoshida N
- 第一作者单位
- Department of Hematology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Japan.Japan
- 通讯作者单位
- Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan.Japan
- 文献类型
- 病例报告
- 期刊
- Internal medicine (Tokyo, Japan)2026 May 1
- 原文标识
- PubMed 41033998 · DOI 10.2169/internalmedicine.6077-25
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