RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Guide to the diagnosis of lymphoid neoplasms in blood and bone marrow: A Bone Marrow Pathology Group approach.
Guide to the diagnosis of lymphoid neoplasms in blood and bone marrow: A Bone Marrow Pathology Group approach.
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本指南提供了针对血液和骨髓标本中所见淋巴系统肿瘤的诊断策略,同时采用国际共识分类和世界卫生组织第五版分类系统。
血液和骨髓淋巴系肿瘤的正确诊断与分类是临床病理医师的职责。本指南提供一份总体诊断路线图,涵盖从初步识别病例到最终分类的全过程。
内容整合血液学、形态学、免疫表型和遗传学特征,涉及通常累及血液和骨髓的各类前体及成熟B细胞、T细胞和NK 细胞肿瘤。
淋巴系肿瘤分类系统为病理医师提供诊断标准,以支持患者照护、治疗选择和结局预测。
本指南依据国际共识分类和世界卫生组织第五版分类系统,为血液及骨髓标本中淋巴系肿瘤的诊断提供策略。指南结合骨髓病理学组成员的经验,为各类疾病提供关键提示,并说明检测要求、鉴别诊断、非肿瘤性模拟病变及其他独特特征。
The successful diagnosis and classification of lymphoid neoplasms in blood and bone marrow is the responsibility of the practicing pathologist. This guide provides a general "roadmap" for this process, from initial case recognition to final classification.
The integration of hematologic, morphologic, immunophenotypic, and genetic features for the full spectrum of precursor and mature B-cell, T-cell, and natural killer-cell neoplasms that typically manifest in blood and bone marrow is included.
Classification systems for lymphoid neoplasms provide criteria for pathologists to render a diagnosis that is optimal for patient care, treatment, and outcome prediction.
This guide provides diagnostic strategies for lymphoid neoplasms encountered in blood and bone marrow specimens using both the International Consensus Classification and the World Health Organization fifth edition classification systems. Key tips are provided for each entity along with testing requirements, differential diagnosis, nonneoplastic mimics, and other unique features based on the experience of the Bone Marrow Pathology Group members.
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