CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤中的 CAR-T 细胞持久性
英文原题：CAR T cell persistence in cancer.
查看英文原题
CAR T cell persistence in cancer.
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中文摘要
CAR-T 细胞疗法属于‘活药物’，即通过基因工程改造T细胞，使其识别并杀伤癌细胞。CAR-T 靶向血液系统肿瘤和实体瘤的主要障碍之一，是其在体内持续性差，从而限制疗效。本综述总结目前对CAR-T 持久性的认识，包括临床观察、患者相关性分析、多组学研究，以及新兴的细胞工程和制造策略。我们还提出一个用于理解CAR-T 持久性的概念框架，以指导临床数据解读，并促进设计效力更强、疗效更好的CAR-T 治疗产品。
展开英文摘要原文
Chimeric antigen receptor T cell (CAR T) therapies are 'living drugs' in which T cells are genetically engineered to recognize and kill cancer cells. A major barrier to progress for CAR T targeting liquid and solid tumors is the poor persistence of these cells in vivo, which limits therapeutic efficacy. In this review, we summarize the field's current understanding of CAR T persistence, including clinical observations, patient correlatives and multiomics approaches, and emerging cell engineering and manufacturing strategies.
We also propose a conceptual framework for CAR T persistence to guide interpretation of clinical data and the design of more potent and efficacious CAR T therapeutics.
论文信息
- 作者
- Mueller KP、Grenier JM、Weber EW
- 第一作者单位
- Department of Pediatrics, Division of Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.United States
- 通讯作者单位
- Department of Pediatrics, Division of Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: weberew@chop.edu.United States
- 文献类型
- 综述
- 期刊
- Trends in cancer2025 Oct
- 原文标识
- PubMed 40973578 · DOI 10.1016/j.trecan.2025.08.014
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