RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
重编程 NK 细胞用于下一代癌症治疗
英文原题：Rewiring natural killer cells for next-generation cancer therapies.
查看英文原题
Rewiring natural killer cells for next-generation cancer therapies.
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中文摘要
利用自然杀伤（NK）细胞的细胞毒性潜力进行癌症免疫治疗已被证明具有挑战性。在本期 Cancer Cell 中，Biederstädt 等人和 Nikolic 等人利用全基因组 CRISPR 筛选揭示了 NK 细胞功能的新型调控因子，为开发下一代 NK 细胞疗法铺平了道路。
展开英文摘要原文
Harnessing the cytotoxic potential of natural killer (NK) cells for cancer immunotherapy has proven challenging. In this issue of Cancer Cell, Biederstädt et al. and Nikolic et al. utilize genome-wide CRISPR screening to uncover novel regulators of NK cell function, paving the way for developing next-generation NK cell therapies.
论文信息
- 作者
- Pfefferle A、Malmberg KJ
- 单位
- Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Precision Immunotherapy Alliance, University of Oslo, Oslo, Norway. Electronic address: aline.pfefferle@ki.se.Sweden
- 期刊
- Cancer cell2025 Nov 10
- 原文标识
- PubMed 40972573 · DOI 10.1016/j.ccell.2025.08.007