CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
增强胶质母细胞瘤中的 T 细胞浸润：挑战与治疗策略的综述
英文原题：Enhancing T cell infiltration in glioblastoma: a review article on challenges and therapeutic strategies.
查看英文原题
Enhancing T cell infiltration in glioblastoma: a review article on challenges and therapeutic strategies.
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中文摘要
本综述重点关注如何增强T细胞浸润胶质母细胞瘤（GBM），同时克服其免疫抑制性肿瘤微环境（TME）。关键策略包括靶向髓源性抑制细胞（MDSC）以减轻免疫抑制，以及将肿瘤相关巨噬细胞（TAM）从免疫抑制性M2表型重新极化为促炎M1表型，从而增强T细胞功能。给予趋化因子有助于吸引更多效应T细胞到达肿瘤部位。免疫检查点抑制剂（ICI）与其他治疗联合可进一步提高T细胞活性。要增强GBM免疫治疗效果，还必须处理TME中的免疫抑制信号，例如转化生长因子β（TGF-β）和白细胞介素-10（IL-10）。
展开英文摘要原文
This review focuses on enhancing T-cell infiltration in glioblastoma (GBM) while overcoming its immunosuppressive tumor microenvironment (TME). Key strategies include targeting myeloid-derived suppressor cells (MDSCs) to reduce immunosuppression and repolarizing tumor-associated macrophages (TAMs) from an M2 (immunosuppressive) phenotype to an M1 (proinflammatory) phenotype to increase T-cell function.
Administering chemokines can help attract more effector T cells to the tumor site. Combining immune checkpoint inhibitors (ICIs) with other treatments can further increase T cell activity. To make immunotherapy more effective in GBM, it is also essential to address the immunosuppressive signals in the TME, such as transforming growth factor beta (TGF- ) and interleukin-10 (IL-10).
论文信息
- 作者
- Habibi MA、Nejati N、Najafi MB、Khodadadiyan A、Dashti M、Lorestani P、Karimizadeh Z、Ahmadpour M
- 第一作者单位
- Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: mohammad.habibi1392@yahoo.com.Iran
- 通讯作者单位
- Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address: Soheil.tavakolpour@gmail.com.Iran
- 文献类型
- 综述
- 期刊
- Cancer treatment and research communications2025
- 原文标识
- PubMed 40961824 · DOI 10.1016/j.ctarc.2025.100999