RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
与免疫检查点抑制剂相关的颅神经病变
英文原题：Cranial neuropathies related to immune checkpoint inhibitors.
查看英文原题
Cranial neuropathies related to immune checkpoint inhibitors.
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中文摘要
在过去十年中，作为免疫检查点抑制剂（ICIs）发挥作用的单克隆抗体（mAbs）已被用于治疗多种类型的癌症。与某些类型的化疗相比，ICIs通常更有效，其通过逆转肿瘤细胞为逃避抗肿瘤免疫反应而诱导的CD8+ T淋巴细胞和NK细胞耗竭，作为针对多种癌症的靶向治疗发挥作用，这与既往的化疗不同。然而，在这种治疗下，患者可能出现影响多个器官和系统的免疫相关不良事件，包括神经系统。因此，我们综述了在接受ICIs进行癌症治疗的患者中，作为神经系统病变表现的颅神经受累情况。
展开英文摘要原文
Over the last decade, monoclonal antibodies (mAbs) that function as immune checkpoint inhibitors (ICIs) have been used to treat various types of cancer. ICIs are often more effective than certain types of chemotherapy by reversing the exhaustion of CD8 + T lymphocytes and NK cells induced by tumor cells to evade the antitumor immune response, acting as a targeted therapy against various cancers, unlike previous chemotherapies.
However, under this treatment, patients may experience immune-related adverse events affecting multiple organs and systems, including the nervous system.
Thus, we reviewed the cranial nerve involvement as a manifestation of nervous system lesions in patients receiving ICIs for cancer treatment.
论文信息
- 作者
- Vieira GD、Boldrini VO、Schlindwen L、de Souza Filho ECP、Schulz ME、de Souza FF、Trevisani JP、Campezato PH
- 单位
- Brazilian Institute of Neuroscience and Neurotechnology, University of Campinas, Campinas, Brazil; Department of Neurology, University of the Joinville Region, Joinville, Brazil. Electronic address: gabrieldedeusvieira@gmail.com.Brazil
- 文献类型
- 综述
- 期刊
- Journal of neuroimmunology2025 Dec 15
- 原文标识
- PubMed 40957152 · DOI 10.1016/j.jneuroim.2025.578752