CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
复发/难治性原发性浆细胞白血病患者中 BCMA CAR-T 细胞的序贯胸腔内注射与静脉输注
英文原题：Sequential intrathoracic injection and intravenous infusion of BCMA CAR-T cells in a patient with relapsed/refractory primary plasma cell leukemia.
查看英文原题
Sequential intrathoracic injection and intravenous infusion of BCMA CAR-T cells in a patient with relapsed/refractory primary plasma cell leukemia.
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中文摘要
原发性浆细胞白血病（pPCL）患者，尤其伴有髓外病变（EMD）的患者，即使接受嵌合抗原受体（CAR）T细胞治疗，预后仍较差。本病例报告描述一名复发/难治性pPCL患者，伴危及生命的恶性胸腔积液（PE），接受胸腔内输注靶向B细胞成熟抗原的CAR-T 细胞治疗。观察到胸腔积液内CAR-T 细胞扩增，白血病细胞计数和胸腔积液量迅速下降。随后进行淋巴清除化疗并静脉输注CAR-T 细胞，患者达到完全缓解，无进展生存期为9个月。本病例凸显局部和全身CAR-T 细胞疗法联合应用治疗复杂EMD病例的潜在优势。
展开英文摘要原文
Patients with primary plasma cell leukemia (pPCL), particularly those with extramedullary disease (EMD), face a poor prognosis even with chimeric antigen receptor (CAR)-T cell therapy. This case report describes a patient with relapsed/refractory pPCL and life-threatening malignant pleural effusion (PE) treated with intrapleural CAR-T cells targeting B-cell maturation antigens.
CAR-T cell expansion within the PE was observed, along with a rapid reduction in leukemia cell count and PE volume. Subsequent lymphodepletion chemotherapy and intravenous CAR-T cell therapy induced complete remission with 9 months of progression-free survival. This case highlights the potential advantages of integrating local and systemic CAR-T cell therapy in managing complex EMD cases.
论文信息
- 作者
- Han W、Wang S、Zhang M、Fu S、Wu W、Zhao H、Wong KW、Yip SF
- 第一作者单位
- Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, 310003, China.China
- 通讯作者单位
- Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, 310003, China. 1313016@zju.edu.cn.China
- 文献类型
- 病例报告
- 期刊
- International journal of hematology2025 Dec
- 原文标识
- PubMed 40931245 · DOI 10.1007/s12185-025-04064-3