CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
天生杀手：利用 NK 细胞治疗癌症
英文原题：Natural born Killers: Harnessing NK cells to treat cancer.
查看英文原题
Natural born Killers: Harnessing NK cells to treat cancer.
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中文摘要
过继性细胞治疗，即采集免疫细胞并将其转移给患者，正在成为许多恶性肿瘤的治疗选择，尤其是血液系统恶性肿瘤，并且在实体瘤和自身免疫性疾病等非恶性疾病中的作用日益增加。先天免疫细胞自然杀伤（NK）细胞的过继转移具有独特的优势，可作为癌症患者的潜在单独疗法或作为其他免疫靶向疗法的辅助疗法，并且相较于T细胞等其他细胞疗法具有若干优势。我们综述了NK细胞作为人类疾病疗法的关键概念，并讨论了在恶性肿瘤中使用NK细胞的关键试验。
展开英文摘要原文
Adoptive cellular therapy, or the collection and transfer of immune cells to patients, is emerging as a treatment option for many malignancies, especially hematologic malignancies, with a growing role in solid tumors and non-malignant conditions such as autoimmune diseases. The adoptive transfer of the innate immune cell natural killer (NK) cells is uniquely poised as a potential therapy alone or as an adjunct to other immune-targeted therapies for patients with cancer, with several advantages over other cell therapies such as T cells.
We review key concepts in NK cells as a therapy for human disease and discuss key trials using NK cells in malignancy.
论文信息
- 作者
- Patell K、Myers K、Mohamed A、Wald D、Selfridge JE
- 第一作者单位
- University Hospitals Seidman Cancer Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.United States
- 通讯作者单位
- University Hospitals Seidman Cancer Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA; University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA; Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44016, USA. Electronic address: evaselfridge@gmail.com.United States
- 文献类型
- 综述
- 期刊
- Best practice & research. Clinical haematology2025 Sep
- 原文标识
- PubMed 40915699 · DOI 10.1016/j.beha.2025.101630