RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
葡萄糖限制：癌症治疗中的双刃剑
英文原题：Glucose restriction: double edged sword in cancer treatment.
查看英文原题
Glucose restriction: double edged sword in cancer treatment.
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中文摘要
葡萄糖限制通常会抑制肿瘤生长。近期Wu等人报告，葡萄糖限制虽能抑制原发肿瘤，却会形成以巨噬细胞为主、缺乏自然杀伤（NK）细胞的转移前生态位（PMN），从而促进肺转移。这项发现为理解调节葡萄糖代谢在癌症治疗中的双重作用提供了新视角。
展开英文摘要原文
Glucose restriction generally limits tumor growth. Recently, Wu et al. reported that glucose restriction inhibits primary tumors but promotes lung metastasis by forming a macrophage-dominated, natural killer (NK) cell-deficient pre-metastatic niche (PMN). This finding provides a new perspective on understanding the dual role of glucose metabolism regulation in cancer treatment.
论文信息
- 作者
- Xia S、Jia D
- 第一作者单位
- Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310058, China; Institution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, 310058, China. Electronic address: xsl89@zju.edu.cn.China
- 通讯作者单位
- Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310058, China; Institution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, 310058, China. Electronic address: gijdjc@zju.edu.cn.China
- 期刊
- Trends in cancer2025 Oct
- 原文标识
- PubMed 40914734 · DOI 10.1016/j.trecan.2025.08.012