CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
干细胞样 CD4⁺ T 细胞介导 T 细胞状态转换以增强肿瘤控制与免疫治疗应答
英文原题：Stem-like CD4+ T cells mediate T-cell state transitions to enhance tumor control and immunotherapy response.
查看英文原题
Stem-like CD4+ T cells mediate T-cell state transitions to enhance tumor control and immunotherapy response.
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中文摘要
免疫治疗近期取得的突破凸显了干样CD4+ T细胞在建立抗肿瘤免疫中的核心作用。这类具备自我更新能力的T细胞可成熟为多种不同效应状态，从而维持肿瘤中的长期免疫应答。它们具有独特的表面蛋白和转录表型，可推动T细胞状态转换并维持肿瘤控制。本综述介绍干样CD4+ T细胞的表型和功能特征、状态转换机制，以及其在肿瘤微环境中的相互作用。我们探讨肿瘤反应性干样CD4+ T细胞如何促使肿瘤消退，尤其关注免疫检查点抑制剂和CAR-T 细胞疗法，并讨论如何防止免疫耐药和复发，以及临床转化面临的挑战。本综述整合最新证据、信号通路和潜在干预措施，突出干样CD4+ T细胞在癌症免疫治疗中的关键作用。
展开英文摘要原文
The recent breakthrough in immunotherapy has emphasized the importance of stem-like CD4+ T cells as the cornerstone to impose anti-tumor immunity. Such self-renewing T cells mature into multiple distinct effector states, which are capable of maintaining long-term immune responses in tumors.
Exhibiting distinctive surface proteins and transcriptional phenotypes, they enable T-cell transitions to maintain tumor control. This review covers their phenotypic and functional characteristics, state transition mechanisms, and interaction within the tumor microenvironment.
We examine how tumor-reactive stem-like CD4+ T cells cause tumor regression, with particular focus on checkpoint inhibitors and CAR-T cell therapy, while addressing the prevention of immune resistance relapse and challenges to clinical translation. This review integrates novel evidence, signaling pathways, and potential interventions to highlight the pivotal role of stem-like CD4+ T cells in cancer immunotherapy.
论文信息
- 作者
- Das M、Kiruthiga C、Kathiresan N、Desai D、Cho WC、Selvaraj C、Kulanthaivel L
- 第一作者单位
- Department of Biomedical Science, Alagappa University, Karaikudi 630003, Tamil Nadu, India.India
- 通讯作者单位
- Department of Biomedical Science, Alagappa University, Karaikudi 630003, Tamil Nadu, India.. Electronic address: dr.langeswaran@gmail.com.India
- 文献类型
- 综述
- 期刊
- International immunopharmacology2025 Nov 14
- 原文标识
- PubMed 40889465 · DOI 10.1016/j.intimp.2025.115432