CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
癌症相关免疫治疗：从心脏毒性到新兴心血管治疗的双向意义：JACC CardioOncology 最新进展综述
英文原题：Cancer-Related Immune Therapies: Bidirectional Implications From Cardiotoxicity to Emerging Cardiovascular Therapeutics: JACC CardioOncology State-of-the-Art Review.
查看英文原题
Cancer-Related Immune Therapies: Bidirectional Implications From Cardiotoxicity to Emerging Cardiovascular Therapeutics: JACC CardioOncology State-of-the-Art Review.
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中文摘要
基于免疫的治疗——包括免疫检查点抑制剂、双特异性T细胞衔接器、CAR-T 细胞和TIL（肿瘤浸润淋巴细胞）——不仅改变了癌症治疗，也引入了显著的心血管并发症，为心脏肿瘤学带来了新的挑战。对心血管免疫相关不良事件的认识不断加深，推动了免疫-心血管界面研究，尤其是信号失调、T细胞过度活化和细胞因子释放。本综述综合了关于免疫检查点在心血管疾病中作用、免疫检查点抑制剂和T细胞诱导心脏毒性的机制，以及免疫检查点调节和CAR-T 细胞疗法在心血管应用中的治疗潜力的最新见解。
展开英文摘要原文
Immune-based therapies-including immune checkpoint inhibitors, bispecific T cell engagers, chimeric antigen receptor T cells, and tumor-infiltrating lymphocytes- not only have transformed cancer treatment, but also have introduced significant cardiovascular complications, posing new challenges for cardio-oncology. Growing recognition of cardiovascular immune-related adverse events has spurred research into the immune-cardiovascular interface, particularly dysregulated signaling, T cell overactivation, and cytokine release.
This review synthesizes recent insights into the role of immune checkpoints in cardiovascular disease, the mechanisms of immune checkpoint inhibitor- and T cell-induced cardiotoxicity, and the therapeutic potential of immune checkpoint modulation and chimeric antigen receptor T cell therapy in cardiovascular applications.
论文信息
- 作者
- Miteva K、Anker MS、Fechner H、Lehmann L、Van Linthout S
- 第一作者单位
- Division of Cardiology, Foundation for Medical Research, Department of Medicine Specialized Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.Switzerland
- 通讯作者单位
- Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany; German Center for Cardiovascular Research, partner site Berlin, Berlin, Germany; Deutsches Herzzentrum der Charité, Klinik für Kardiologie, Angiologie und Intensivmedizin, Campus Virchow-Klinikum, Berlin, Germany. Electronic address: sophie.van-linthout@bih-charite.de.Germany
- 文献类型
- 综述
- 期刊
- JACC. CardioOncology2025 Aug
- 原文标识
- PubMed 40841107 · DOI 10.1016/j.jaccao.2025.06.008
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