CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
脑膜瘤肿瘤免疫微环境特征：TIL（肿瘤浸润淋巴细胞）聚集与肿瘤分级的相关性
英文原题：Characterization of Tumor Immune Microenvironment in Meningiomas: Correlation of Tumor-infiltrating Lymphocyte Aggregates With Tumor Grade.
查看英文原题
Characterization of Tumor Immune Microenvironment in Meningiomas: Correlation of Tumor-infiltrating Lymphocyte Aggregates With Tumor Grade.
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研究概要
脑膜瘤的 TIME 因肿瘤级别而表现出不同的免疫特征，其特征是高级别肿瘤中存在 TIL 聚集以及协调的 CD4+和 CD8+ T 细胞浸润。这些发现可能有助于深入了解脑膜瘤的免疫景观，并支持针对 TIME 的免疫治疗策略的开发。
研究思路结论见上方概要
恶性脑膜瘤是侵袭性颅内肿瘤，复发率高且治疗选择有限。肿瘤免疫微环境（TIME）在肿瘤进展和治疗反应中起关键作用。然而，其在脑膜瘤中的作用仍 largely 未知。本研究旨在分析脑膜瘤 TIME 中的TIL（肿瘤浸润淋巴细胞）（TILs），并探讨其与临床参数的相关性。
使用诊断为脑膜瘤患者的肿瘤标本（1级12例；2级10例），通过多色免疫组织化学和QuPath软件定量CD4+ T细胞、CD8+ T细胞、CD20+ B细胞和组织驻留记忆T细胞的密度。结果与临床参数（包括肿瘤分级）一起分析。
单个 TIL 亚群的密度与肿瘤分级或患者术后神经功能无关。在 2 级脑膜瘤中观察到 TIL 聚集；在 1 例中观察到大量 B 细胞簇伴少量滤泡辅助性 T 细胞，提示存在未成熟的三级淋巴结构。在 2 级脑膜瘤中观察到 CD4+ 和 CD8+ T 细胞密度之间呈正相关，但在 1 级中未观察到。
展开英文摘要原文
Using tumor specimens from patients diagnosed with meningioma (grade 1, 12 cases; grade 2, 10 cases), the densities of CD4+ T-cells, CD8+ T-cells, CD20+ B-cells, and tissue-resident memory T-cells were quantified using multicolor immunohistochemistry and the QuPath software. The results were analyzed along with clinical parameters, including tumor grades.
The density of individual TIL subsets did not correlate with the tumor grades or patients' postoperative neurological function. TIL aggregates were observed in grade 2 meningiomas; clusters of abundant B-cells with a few follicular helper T-cells were observed in one case, indicating the presence of immature tertiary lymphoid structures. A positive correlation was observed between the densities of CD4+ and CD8+ T-cells in grade 2 meningiomas but not in grade 1.
The TIME in meningiomas exhibits distinct immune profiles by tumor grade, characterized by the presence of TIL aggregates and coordinated CD4+ and CD8+ T-cell infiltration in higher-grade tumors. These findings may provide insights into the immune landscape of meningiomas and support the development of immunotherapeutic strategies targeting the TIME.
论文信息
- 作者
- Inomo T、Ohno M、Nagasaka T、Kuramitsu S、Ito E、Watanabe T、Fujita M
- 第一作者单位
- Department of Neurosurgery, Aichi Medical University, Nagakute, Japan.Japan
- 通讯作者单位
- Center for Medical Education and Clinical Training, Kindai University Faculty of Medicine, Osaka-Sayama, Japan mfujita47-umn@umin.ac.jp.Japan
- 期刊
- Anticancer research2025 Aug
- 原文标识
- PubMed 40750403 · DOI 10.21873/anticanres.17710