RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
乳腺癌免疫景观的亚型和种族特异性变异：治疗意义
英文原题：Subtype- and race-specific variations in the immune landscape of breast cancer: therapeutic implications.
查看英文原题
Subtype- and race-specific variations in the immune landscape of breast cancer: therapeutic implications.
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中文摘要
乳腺癌是一种异质性疾病，具有不同的分子亚型，对黑人女性的影响尤为严重。免疫细胞是肿瘤微环境的关键组成部分，影响肿瘤生长和治疗结局。在此，我们探讨了TNBC与非TNBC亚型之间的免疫景观差异，评估是否存在种族特异性模式。与非TNBC相比，TNBC显示B细胞、Treg细胞、Th1细胞和CD8+细胞浸润更高，肥大细胞更少。按种族比较显示，白人TNBC的Th1细胞多于黑人TNBC，而黑人非TNBC表现出更高的NK和Treg细胞但更低的DC。KEGG通路分析发现TNBC存在免疫抑制，黑人患者无论分子亚型如何均表现出相同情况。更高的TAM和更低的T细胞浸润与转移性疾病相关。在白人患者中，较低的免疫细胞（特别是T细胞、DC和NK细胞）与更多转移相关，但在黑人患者中并非如此。这些种族和亚型特异性的免疫差异可能指导定制化免疫治疗。
展开英文摘要原文
Breast cancer is a heterogeneous disease with distinct molecular subtypes that disproportionately affects Black women. Immune cells are a key component of the tumor microenvironment, influencing tumor growth and treatment outcomes.
Here, we explored immune landscape differences between TNBC and non-TNBC subtypes, assessing any race-specific patterns. TNBC showed higher infiltration of B-cells, Treg cells, Th1 cells, and CD8+ cells, and fewer mast cells than non-TNBC. Race-wise comparisons revealed that White TNBC had more Th1 cells than Black TNBC, while Black non-TNBC exhibited higher NK and Treg cells but lower DCs.
KEGG pathway analysis identified immunosuppression in TNBC, with Black patients exhibiting the same regardless of molecular subtype. Higher TAM and lower T-cell infiltration were linked to metastatic disease. In White patients, lower immune cells (particularly T-cells, DCs, and NK cells) correlated with more metastasis, but not in Black patients. These race- and subtype-specific immune differences may guide tailored immunotherapies.
论文信息
- 作者
- Sharma A、Sudan SK、Vikramdeo KS、Khan MA、Tahir M、Carter JE、Kendall T、Nelson C
- 第一作者单位
- Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA.United States
- 通讯作者单位
- Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA. ssingh3@umc.edu.United States
- 期刊
- NPJ breast cancer2025 Jul 24
- 原文标识
- PubMed 40707500 · DOI 10.1038/s41523-025-00799-8
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