CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
分子靶向药物联合 CAR-T 细胞治疗多发性骨髓瘤的应用与前景
英文原题：Applications and prospects of molecularly targeted drugs combined with CAR-T cell therapy to treat multiple myeloma.
查看英文原题
Applications and prospects of molecularly targeted drugs combined with CAR-T cell therapy to treat multiple myeloma.
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中文摘要
CAR-T（CAR-T）细胞疗法是一种精准免疫疗法，在治疗某些类型的癌症方面显示出有希望的结果，尽管受到抗原逃逸、肿瘤微环境（TME）抑制和CAR-T 细胞耗竭的限制。分子靶向药物可以通过靶向针对癌症的关键信号转导来增强抗癌疗效，为优化CAR-T 细胞疗法提供了线索。此外，分子靶向药物协同辅助CAR-T 细胞转化TME，增强抗癌活性并抑制免疫逃逸。它们的联合应用已迅速成为多发性骨髓瘤（MM）个体化治疗研究的热点。在本综述中，我们描述了在针对MM的CAR-T 细胞疗法联合中常用的分子靶向药物。
展开英文摘要原文
Chimeric antigen receptor T (CAR-T) cell therapy, a type of precision immunotherapy, has shown promising outcomes in treating certain types of cancers, although limited by the antigen escape, suppression on the tumor microenvironment (TME), and CAR-T cell depletion. Molecularly targeted drugs can enhance the anti-cancer efficacy by targeting key signal transductions against cancers, providing a clue for optimizing the CAR-T cell therapy.
Moreover, molecularly targeted drugs synergistically assist CAR-T cells to transform the TME, boost anti-cancer activities and inhibit immune escape. Their combination has rushed into the spotlight of research on individualized treatments for multiple myeloma (MM). In the present review, we described frequently used molecularly targeted drugs in the combination of CAR-T cell therapy against MM.
论文信息
- 作者
- Xu Y、Mao J
- 第一作者单位
- Department of Hematology, The First People's Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China.China
- 通讯作者单位
- Department of Hematology, The First People's Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China. Electronic address: mjping19810211@163.com.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Best practice & research. Clinical haematology2025 Jun
- 原文标识
- PubMed 40701744 · DOI 10.1016/j.beha.2025.101633