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将细胞治疗前移至 Ph(+) B 细胞急性淋巴细胞白血病一线治疗

英文原题:Moving cellular therapies to the front line for Ph(+) B cell acute lymphoblastic leukemia.

查看英文原题

Moving cellular therapies to the front line for Ph(+) B cell acute lymphoblastic leukemia.

PubMed 2025/07/15(内容时间) Cell Rep Med Q1 · IF 14(JCR 2025)

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中文摘要

由于化疗的局限性,无化疗方案作为 B 细胞急性淋巴细胞白血病(B-ALL)的一线治疗日益受到关注。Zhang 及其同事开展了首个将 CAR-T 纳入 Ph + B-ALL 一线治疗的试验,展现出显著的疗效和耐受性。1。

展开英文摘要原文

Chemotherapy-free regimens have gained increasing attention as frontline treatments for B cell acute lymphoblastic leukemia (B-ALL) due to the limitations of chemotherapy. Zhang and colleagues conducted the first trial incorporating CAR-T into Ph + B-ALL frontline treatment, demonstrating remarkable efficacy and tolerability. 1 .

论文信息

作者
Feng Y、Leveille E、Park JH、Müschen M
第一作者单位
Center of Molecular and Cellular Oncology, Yale University, New Haven, CT 06511, USA.United States
通讯作者单位
Center of Molecular and Cellular Oncology, Yale University, New Haven, CT 06511, USA. Electronic address: markus.muschen@yale.edu.United States
期刊
Cell reports. Medicine2025 Jul 15
原文标识
PubMed 40669449 · DOI 10.1016/j.xcrm.2025.102184