RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
白细胞介素-17 家族在癌症中的免疫生物学功能及治疗应用
英文原题：The immunobiological functions and therapeutic applications of interleukin-17 family in cancer.
查看英文原题
The immunobiological functions and therapeutic applications of interleukin-17 family in cancer.
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中文摘要
白细胞介素-17（IL-17）家族细胞因子在免疫应答和炎症过程中发挥关键作用，显著影响多种生理和病理状态。本综述探讨了IL-17的免疫生物学功能，重点关注其多样的细胞来源，包括辅助性T细胞17（Th17）细胞、γδ T细胞、固有淋巴样细胞（ILCs）、中性粒细胞和自然杀伤T（NKT）细胞，以及相关信号通路。特别关注IL-17在癌症中的作用，其表现出促肿瘤和抗肿瘤双重效应，通过JAK/STAT、NF-κB和PI3K/AKT等多种信号级联影响肿瘤增殖、血管生成、转移和耐药性。理解这些机制凸显了IL-17作为调节免疫应答和改善癌症治疗的潜在治疗靶点。
展开英文摘要原文
Interleukin-17 (IL-17) family cytokines play a pivotal role in immune responses and inflammatory processes, significantly impacting various physiological and pathological conditions. This review explores the immunobiological functions of IL-17, focusing on its diverse cellular sources, including T helper 17 (Th17) cells, γδ T cells, innate lymphoid cells (ILCs), neutrophils, and natural killer T (NKT) cells, and signaling pathways.
Special attention is given to IL-17 involvement in cancer, where it exhibits both pro-tumorigenic and anti-tumorigenic effects, influencing tumor proliferation, angiogenesis, metastasis, and drug resistance through various signaling cascades such as JAK/STAT, NF-κB, and PI3K/AKT. Understanding these mechanisms highlights IL-17 as a potential therapeutic target for modulating immune responses and improving cancer treatments.
论文信息
- 作者
- Mansuri N、Mohamed AH、Ahsan M、Ali SA、Qureshi MA、A Aldhaaban W、Mallick AK、Mohammed MED
- 第一作者单位
- Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.Saudi Arabia
- 通讯作者单位
- Department of Optometry Techniques, Technical College Al-Mussaib, Al-Furat Al-Awsat Technical University, Najaf, Iraq. Electronic address: asmaa.muhammed@atu.edu.iq.United States
- 文献类型
- 综述
- 期刊
- Current research in translational medicine2025 Dec
- 原文标识
- PubMed 40644929 · DOI 10.1016/j.retram.2025.103527