CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
青少年复发性 B 细胞急性淋巴细胞白血病伴多次全身感染史患者获得性二尖瓣下动脉瘤：一例病例报告
英文原题：Acquired Submitral Aneurysm in an Adolescent with Relapse of B-cell Acute Lymphoblastic Leukemia and History of Multiple Systemic Infections: A Case Report.
查看英文原题
Acquired Submitral Aneurysm in an Adolescent with Relapse of B-cell Acute Lymphoblastic Leukemia and History of Multiple Systemic Infections: A Case Report.
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中文摘要
我们报告一例14岁男孩，有B细胞急性淋巴细胞白血病（ALL）病史、多次多种微生物感染，以及近期因心包积液需行心包穿刺术，偶然发现二尖瓣下左心室室壁瘤。同时，他出现B细胞ALL复发，表现为脑脊液中存在淋巴母细胞。决定在开始全身化疗前先行室壁瘤手术修复。患者通过修复二尖瓣环断裂成功完成了室壁瘤修复。该室壁瘤可能由部分治疗的心内膜炎引起，削弱了二尖瓣房室交界处，导致裂开。术后恢复顺利，数月后他能够接受CAR-T 细胞治疗。
展开英文摘要原文
We present the case of a 14-year-old boy with history of B-cell acute lymphoblastic leukemia (ALL), multiple polymicrobial infections, and recent pericardial effusion requiring pericardiocentesis who was incidentally found to have a submitral left ventricular aneurysm. Concurrently, he developed a relapse of his B-cell ALL as demonstrated by the presence of lymphoblasts in his cerebrospinal fluid.
The decision was made to proceed with surgical repair of the aneurysm prior to initiation of systemic chemotherapy. The patient underwent a successful repair of the aneurysm through repair of the mitral valve annular disruption. The aneurysm is likely to be due to partially treated endocarditis, weakening the mitral valve atrioventricular junction, resulting in dehiscence. Recovery post-operatively was uneventful and he was able to undergo CAR-T cell therapy several months later.
论文信息
- 作者
- Crilly CJ、Carvalho K、Winlaw DS、Cornicelli M
- 单位
- Division of Cardiology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. ccrilly@luriechildrens.org.United States
- 文献类型
- 病例报告
- 期刊
- Pediatric cardiology2026 Apr
- 原文标识
- PubMed 40643604 · DOI 10.1007/s00246-025-03947-w
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