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21 世纪癌症研究:近期进展与未来展望

英文原题:Cancer Research in the 21st Century: Recent Advances and Future Perspectives.

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Cancer Research in the 21st Century: Recent Advances and Future Perspectives.

PubMed 2025/07/09(内容时间) Zhongguo Ying Yong Sheng Li Xue Za Zhi

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研究概要

基因组学、人工智能和免疫疗法融入肿瘤学实践标志着向精准医学的转变。尽管这些进步显著改善了患者护理,但治疗耐药、可及性差异以及新型疗法的高成本等挑战依然存在。持续开展跨学科研究、制定公平的医疗政策以及对新兴技术进行投资,对于充分实现现代癌症护理的益处至关重要。

研究思路结论见上方概要

癌症仍然是全球主要的健康问题,每年导致近 1000 万人死亡。尽管其复杂性和异质性,过去二十年癌症研究的重大进展改变了癌症诊断、治疗和预防的格局。值得注意的是,个性化医疗与技术创新的结合带来了更加精准、有效和个性化的护理策略。材料:本综述利用了同行评审的文章、临床试验数据以及 2015 年至 2025 年间发表的最新荟萃分析。使用“癌症治疗”、“个性化医疗”、“癌症诊断”、“免疫治疗”和“癌症预防”等关键词对包括 PubMed、Scopus 和 Web of Science 在内的主要数据库进行了搜索。

采用系统评价方法,重点关注报告癌症治疗方式(例如靶向治疗、免疫治疗)、诊断技术(例如液体活检、基于人工智能的成像)和预防策略(例如疫苗接种、基因筛查)方面取得重大进展的研究。文章的选择基于相关性、影响力和新近度,优先考虑临床研究和高影响力的评论。

免疫检查点抑制剂、CAR-T 细胞疗法和分子靶向药物等新兴疗法已显示出多种癌症类型的生存率和缓解率有所提高。诊断创新,包括新一代测序和非侵入性液体活检,增强了治疗反应的早期检测和监测。 HPV 和 HBV 疫苗接种以及遗传风险分析等预防措施降低了多种可预防癌症的发病率。个性化医疗方法使得基于个体遗传和分子特征的治疗决策成为可能,从而改善治疗结果并减少不良反应。

展开英文摘要原文

A systematic review approach was applied, focusing on studies that reported significant advancements in cancer treatment modalities (e.g., targeted therapy, immunotherapy), diagnostic technologies (e.g., liquid biopsy, AI-based imaging), and preventive strategies (e.g., vaccination, genetic screening). Articles were selected based on relevance, impact, and recency, with a preference for clinical studies and high-impact reviews.

Emerging therapies such as immune checkpoint inhibitors, CAR-T cell therapy, and molecularly targeted agents have shown improved survival and response rates in several cancer types. Diagnostic innovations, including next-generation sequencing and non-invasive liquid biopsies, have enhanced early detection and monitoring of treatment response. Preventive measures, such as HPV and HBV vaccination and genetic risk profiling, have reduced the incidence of several preventable cancers. Personalized medicine approaches have enabled treatment decisions based on individual genetic and molecular profiles, leading to improved therapeutic outcomes and reduced adverse effects. DISCUSSION: The integration of genomics, artificial intelligence, and immunotherapy into oncology practice marks a shift toward precision medicine. While these advances have significantly improved patient care, challenges such as treatment resistance, access disparities, and the high cost of novel therapies remain. Continued interdisciplinary research, equitable healthcare policies, and investment in emerging technologies are essential to fully realize the benefits of modern cancer care.

论文信息

作者
Patole VP、Shinde NV、Chandak SM、Satalkar AT
单位
Department of Pharmaceutical Chemistry, SMBT College of Pharmacy Dhamangaon, Nashik, M.S. India-422403, Affiliated to Savitribai Phule Pune University, India.India
文献类型
系统综述
期刊
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology2025 Jul 9
原文标识
PubMed 40628691 · DOI 10.62958/j.cjap.2025.018