CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
IL-15 在 CAR 工程化中：实现疗效与安全性的平衡
英文原题：IL-15 in CAR engineering: striking an efficacy-safety balance.
查看英文原题
IL-15 in CAR engineering: striking an efficacy-safety balance.
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中文摘要
白细胞介素（IL）-15工程化嵌合抗原受体（CAR）细胞疗法在近期临床试验中已显示出对血液系统恶性肿瘤和实体瘤均有前景可观抗肿瘤疗效。然而，在传统CAR-T 细胞中主要观察到细胞因子释放综合征（CRS）毒性增加，这凸显出在IL-15增强型CAR疗法中平衡安全性与疗效以供临床应用的必要性。
展开英文摘要原文
Interleukin (IL)-15 engineering in chimeric antigen receptor (CAR)-cell therapy has demonstrated promising antitumor efficacy against both hematological malignancies and solid tumors in recent clinical trials.
However, increased cytokine release syndrome (CRS) toxicity is primarily observed in conventional CAR-T cells, underscoring the need to balance safety and efficacy in IL-15-enhanced CAR therapy for clinical application.
论文信息
- 作者
- Li YR、Zhu Y、Yang L
- 第一作者单位
- Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: charlie.li@ucla.edu.United States
- 通讯作者单位
- Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Parker Institute for Cancer Immunotherapy, University of California, Los Angeles, Los Angeles, CA 90095, USA; Goodman-Luskin Microbiome Center, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: liliyang@ucla.edu.United States
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Trends in molecular medicine2025 Nov
- 原文标识
- PubMed 40537350 · DOI 10.1016/j.molmed.2025.05.014