CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗的神经毒性负担
英文原题：The neurological toll of CAR T cell therapy.
查看英文原题
The neurological toll of CAR T cell therapy.
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中文摘要
随着 CAR-T 细胞疗法在临床中的应用日益广泛，理解其治疗癌症后的急性及长期不良事件仍是重要研究领域。本期《Cell》中，Geraghty、Acosta-Alvarez 等人研究了动物模型中接受 CAR-T 细胞疗法后出现认知功能下降的机制，涉及血液系统恶性肿瘤、实体瘤及中枢神经系统（CNS）恶性肿瘤。
展开英文摘要原文
Understanding acute and long-term adverse events following CAR T cell therapy for cancer remains a crucial area of investigation as CAR T cells become more prominent in the clinic. In this issue of Cell, Geraghty and Acosta-Alvarez et al. investigate the mechanisms underlying cognitive decline in animal models following CAR T cell therapy for hematological, solid, and CNS malignancies.
论文信息
- 作者
- Ward MB、Krenciute G
- 第一作者单位
- Department of Bone Marrow Transplantation and Cellular Therapy (BMTCT), St. Jude Children's Research Hospital, Memphis, TN, USA.United States
- 通讯作者单位
- Department of Bone Marrow Transplantation and Cellular Therapy (BMTCT), St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address: giedre.krenciute@stjude.org.United States
- 期刊
- Cell2025 Jun 12
- 原文标识
- PubMed 40513552 · DOI 10.1016/j.cell.2025.04.031