CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
下一代免疫治疗设计与工具的洞见：分子机制与治疗前景
英文原题：Insights into next-generation immunotherapy designs and tools: molecular mechanisms and therapeutic prospects.
查看英文原题
Insights into next-generation immunotherapy designs and tools: molecular mechanisms and therapeutic prospects.
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中文摘要
免疫疗法彻底改变了肿瘤治疗模式，尤其是CAR-T 细胞疗法，已成为治疗血液系统恶性肿瘤的重要里程碑。然而，靶点异质性或突变导致的肿瘤耐药，仍是免疫治疗面临的棘手难题。本综述阐明下一代免疫治疗工具的分子机制和治疗潜力，涵盖基因工程免疫细胞、多特异性抗体和细胞衔接器，重点讨论增强个体化免疫治疗疗效的多靶点策略。开发基于逻辑门调控的回路、适配器介导的CAR、多特异性抗体和细胞衔接器，有望在识别肿瘤信号的同时减少不良反应。最后，我们介绍促进个体化免疫治疗的基因递送、基因编辑及其他技术，并讨论人工智能在基因编辑免疫细胞方面的前景。
展开英文摘要原文
Immunotherapy has revolutionized the oncology treatment paradigm, and CAR-T cell therapy in particular represents a significant milestone in treating hematological malignancies. Nevertheless, tumor resistance due to target heterogeneity or mutation remains a Gordian knot for immunotherapy. This review elucidates molecular mechanisms and therapeutic potential of next-generation immunotherapeutic tools spanning genetically engineered immune cells, multi-specific antibodies, and cell engagers, emphasizing multi-targeting strategies to enhance personalized immunotherapy efficacy.
Development of logic gate modulation-based circuits, adapter-mediated CARs, multi-specific antibodies, and cell engagers could minimize adverse effects while recognizing tumor signals. Ultimately, we highlight gene delivery, gene editing, and other technologies facilitating tailored immunotherapy, and discuss the promising prospects of artificial intelligence in gene-edited immune cells.
论文信息
- 作者
- Qin H、Zhou Z、Shi R、Mai Y、Xu Y、Peng F、Cheng G、Zhang P
- 第一作者单位
- Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People's Republic of China.China
- 通讯作者单位
- Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People's Republic of China. christy_luq@csu.edu.cn.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Journal of hematology & oncology2025 Jun 7
- 原文标识
- PubMed 40483473 · DOI 10.1186/s13045-025-01701-6
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →