RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Changes in T-lymphocyte subpopulations in patients with colorectal cancer before and after acupoint catgut embedding acupuncture observation.
Changes in T-lymphocyte subpopulations in patients with colorectal cancer before and after acupoint catgut embedding acupuncture observation.
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本研究旨在探讨结直肠癌(CRC)患者穴位埋线(ACE)针刺观察前后外周血T淋巴细胞亚群的变化。采用便利抽样法,选取2017年4月至2022年5月就诊的80例CRC手术患者作为研究样本。将患者随机分为对照组(n=40,接受常规化疗)和观察组(n=40,接受额外4周ACE针刺)。观察组完全缓解率和部分缓解率高于对照组,但差异无统计学意义(P>0.05)。观察组化疗期间CD3+、CD4+T淋巴细胞和NK 细胞的减少幅度较小。与对照组相比,观察组干预后CD3+和CD4+T细胞百分比显著升高,而CD8+T细胞水平降低。CD4+/CD8+比值处于较高水平,差异有统计学意义(P<0.05)。针刺疗法可维持CRC患者化疗期间外周血T淋巴细胞亚群的正常分布,从而更好地维持患者的免疫状态。
This study aims to explore changes in peripheral blood T-lymphocyte subsets in colorectal cancer (CRC) patients before and after acupoint catgut embedding (ACE) acupuncture observation. Eighty CRC surgical patients who visited from April 2017 to May 2022 were selected as study samples using the convenience sampling method. Patients were randomly divided into a control group ( n = 40, receiving conventional chemotherapy) and an observation group ( n = 40, receiving 4 weeks of additional ACE acupuncture). The observation group showed higher rates of complete and partial remission compared to the control, though the difference was not statistically significant ( P > 0.
05). The observation group experienced less reduction in CD 3+ , CD 4+ T lymphocytes, and natural killer cells during chemotherapy. Compared with the control group, the percentage of CD 3+ and CD 4+ T cells in the observation group significantly increased after the intervention, while CD 8+ T-cell levels decreased.
The CD 4+ /CD 8+ ratio was at a higher level, and the discrepancy was statistically obvious ( P < 0. 05). Acupuncture therapy can maintain the normal distribution of peripheral blood T-lymphocyte subpopulations during chemotherapy in patients with CRC, thus better maintaining the immune status of patients.
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